Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 13/20 | 0.63 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | NOS3 | P29474 | 1/20 | 0.48 |
| ▸ | NOS1 | P29475 | 1/20 | 0.48 |
| ▸ | NOS2 | P35228 | 1/20 | 0.48 |
| ▸ | ESRRG | P62508 | 2/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | CCND1 | P24385 | 1/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21671816 | 0.98 | HTR7 (0.64) | HTR7HTR2AHTR2CNOS3NOS1 | |
| SCHEMBL13783290 | 0.87 | HTR7 (0.54) | HTR7HTR2AHTR2CNOS3NOS1 | |
| SCHEMBL23927836 | 0.82 | HTR7 (0.67) | HTR7HTR2AHTR2CPRMT5 | |
| SCHEMBL4263907 | 0.82 | HTR7 (0.54) | HTR7NOS3NOS1NOS2ESRRG | |
| SCHEMBL23927863 | 0.82 | HTR7 (0.61) | HTR7HTR2AHTR2CNOS3NOS1 | |
| SCHEMBL2262498 | 0.82 | HTR7 (0.54) | HTR7NOS3NOS1NOS2ESRRG | |
| SCHEMBL16705724 | 0.81 | HTR7 (0.54) | HTR7NOS3NOS1NOS2ESRRG | |
| SCHEMBL14594152 | 0.81 | HTR7 (0.66) | HTR7NOS3NOS1NOS2ESRRG | |
| SCHEMBL23927918 | 0.81 | HTR7 (0.68) | HTR7HTR2AHTR2CPRMT5 | |
| SCHEMBL13783320 | 0.80 | NOS3 (0.52) | HTR7HTR2AHTR2CNOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9394268-B2 | (E)-1-(5-methoxy-2,2-dimethyl-2H-chromen-8-yl)-3-(4-methoxyphenyl)prop-2-en-1-one and analogs thereof, as well as preparation method and use thereof | SICHUAN UNIVERSITY (CN) | 2016-07-19 | — | — | US | disclosed |
| US-20150133659-A1 | (E)-1-(5-METHOXY-2,2-DIMETHYL-2H-CHROMEN-8-YL)-3-(4-METHOXYPHENYL)PROP-2-EN-1-ONE AND ANALOGS THEREOF, AS WELL AS PREPARATION METHOD AND USE THEREOF | SICHUAN UNIVERSITY (CN) | 2015-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150133659-A1 | (E)-1-(5-METHOXY-2,2-DIMETHYL-2H-CHROMEN-8-YL)-3-(4-METHOXYPHENYL)PROP-2-EN-1-ONE AND ANALOGS THEREOF, AS WELL AS PREPARATION METHOD AND USE THEREOF | ECE1, CMA1, MME | HTR7 246/4885HTR2A 369/4885HTR2C 370/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.