Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG | P00747 | 1/20 | 0.45 |
| ▸ | PLAU | P00749 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 4/20 | 0.44 |
| ▸ | CCND1 | P24385 | 4/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | RORA | P35398 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | RORB | Q92753 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16479302 | 0.90 | HTR7 (0.46) | PLGPLAUCDK4CCND1HTR7 | |
| SCHEMBL19526836 | 0.87 | HTR7 (0.57) | CDK4CCND1HTR7PGRRORA | |
| SCHEMBL22930066 | 0.84 | PLG (0.41) | PLGPLAUCDK4CCND1HTR7 | |
| SCHEMBL18856958 | 0.83 | HTR7 (0.44) | PLGPLAUCDK4CCND1HTR7 | |
| SCHEMBL16216132 | 0.83 | HTR7 (0.44) | PLGPLAUCDK4CCND1HTR7 | |
| SCHEMBL14594165 | 0.83 | ACACB (0.47) | PLGPLAUCDK4CCND1HTR7 | |
| SCHEMBL12257510 | 0.82 | RORC (0.45) | PLGPLAUHTR7RORCCYP1A2 | |
| SCHEMBL18856946 | 0.81 | HTR2A (0.55) | PLGPLAUCDK4CCND1HTR7 | |
| SCHEMBL9371544 | 0.81 | PLG (0.48) | PLGPLAUKDM4EOXER1MTNR1A | |
| SCHEMBL14117445 | 0.81 | GLO1 (0.46) | PLGPLAUCDK4CCND1HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017082924-A1 | PEPTIDE AND PEPTIDE MIMETIC BINDING ANTAGONISTS OF POLO-LIKE KINASE 1 POLO BOX DOMAIN AND METHODS OF USE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES (US) | 2017-05-18 | — | — | WO | disclosed |