Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | GAA | P10253 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | THRA | P10827 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5539965 | 0.87 | MAPT (0.59) | MAPTLMNAGAAKDM4ESMN1; SMN2 | |
| SCHEMBL5539971 | 0.87 | MAPT (0.76) | MAPTLMNAGAAKDM4ESMN1; SMN2 | |
| SCHEMBL27610366 | 0.86 | MAPT (0.74) | MAPTLMNAGAAKDM4ESMN1; SMN2 | |
| SCHEMBL3313011 | 0.86 | MAPT (0.58) | MAPTLMNAGAAKDM4ESMN1; SMN2 | |
| SCHEMBL15569212 | 0.85 | MAPT (0.50) | MAPTLMNAGAAKDM4ESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL31540771 | 0.85 | MAPT (0.57) | MAPTLMNAGAAKDM4ESMN1; SMN2 | |
| SCHEMBL2465974 | 0.84 | DRD2 (0.55) | MAPTLMNAGAAALDH1A1THRB | |
| SCHEMBL22578809 | 0.84 | LMNA (0.58) | MAPTLMNAGAAKDM4ESMN1; SMN2 | |
| SCHEMBL30643640 | 0.84 | MAPT (0.55) | MAPTLMNAGAAKDM4ESMN1; SMN2 | |
| SCHEMBL28072006 | 0.84 | MAPT (0.56) | MAPTLMNAGAAKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2473504-A2 | HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK | Bioenergenix (US) | 2012-07-11 | — | — | EP | disclosed |
| WO-2011028947-A2 | HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK | BIOENERGENIX (US) | 2011-03-10 | — | — | WO | disclosed |