SCHEMBL1459682

SCHEMBL1459682

CCCCOC(=O)N1CCN(c2ccccc2)CC1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 9/20 0.57
LMNA P02545 4/20 0.57
GAA P10253 4/20 0.57
KDM4E B2RXH2 1/20 0.57
SMN1; SMN2 Q16637 6/20 0.56
POLB P06746 1/20 0.56
NPSR1 Q6W5P4 1/20 0.54
NPC1 O15118 3/20 0.52
RAB9A P51151 3/20 0.52
ALDH1A1 P00352 5/20 0.52
THRA P10827 1/20 0.50
THRB P10828 1/20 0.50
KMT2A Q03164 2/20 0.49
TP53 P04637 1/20 0.49
NFKB1 P19838 1/20 0.49
NFKB2 Q00653 1/20 0.49
RELA Q04206 1/20 0.49
MAPK1 P28482 1/20 0.49
HTT P42858 1/20 0.49
MEN1 O00255 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5539965 0.87 MAPT (0.59) MAPTLMNAGAAKDM4ESMN1; SMN2
SCHEMBL5539971 0.87 MAPT (0.76) MAPTLMNAGAAKDM4ESMN1; SMN2
SCHEMBL27610366 0.86 MAPT (0.74) MAPTLMNAGAAKDM4ESMN1; SMN2
SCHEMBL3313011 0.86 MAPT (0.58) MAPTLMNAGAAKDM4ESMN1; SMN2
SCHEMBL15569212 0.85 MAPT (0.50) MAPTLMNAGAAKDM4ESMN1; SMN2
Hydrochloric Acid SCHEMBL31540771 0.85 MAPT (0.57) MAPTLMNAGAAKDM4ESMN1; SMN2
SCHEMBL2465974 0.84 DRD2 (0.55) MAPTLMNAGAAALDH1A1THRB
SCHEMBL30643640 0.84 MAPT (0.55) MAPTLMNAGAAKDM4ESMN1; SMN2
SCHEMBL22578809 0.84 LMNA (0.58) MAPTLMNAGAAKDM4ESMN1; SMN2
SCHEMBL28072006 0.84 MAPT (0.56) MAPTLMNAGAAKDM4ESMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2473504-A2 HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK Bioenergenix (US) 2012-07-11 EP disclosed
WO-2011028947-A2 HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK BIOENERGENIX (US) 2011-03-10 WO disclosed