Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15566418 | 0.83 | — | — | |
| SCHEMBL513659 | 0.79 | EPHX2 (0.35) | — | |
| SCHEMBL8137468 | 0.75 | MAPK1 (0.33) | MAPK1 | |
| SCHEMBL7014119 | 0.74 | MAPK1 (0.33) | MAPK1 | |
| SCHEMBL8135029 | 0.71 | GABRA1 (0.33) | MAPK1 | |
| SCHEMBL16774517 | 0.70 | MAPK1 (0.39) | MAPK1 | |
| SCHEMBL16774516 | 0.70 | MAPK1 (0.39) | MAPK1 | |
| SCHEMBL6075300 | 0.70 | PDK4 (0.30) | — | |
| SCHEMBL29654701 | 0.70 | P2RX7 (0.34) | MAPK1 | |
| SCHEMBL6225316 | 0.70 | MAPK1 (0.30) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3386511-A1 | METHODS FOR TREATING HUNTINGTON'S DISEASE | PTC Therapeutics, Inc. (US) | 2018-10-17 | — | — | EP | disclosed |
| WO-2017100726-A1 | METHODS FOR TREATNG HUNTINGTON'S DISEASE | PTC THERAPEUTICS, INC. (US) | 2017-06-15 | — | — | WO | disclosed |
| EP-2480529-A1 | INDOLE DERIVATIVES AS CRAC MODULATORS | F. Hoffmann-La Roche AG (CH) | 2012-08-01 | — | — | EP | disclosed |
| WO-2011036130-A1 | INDOLE DERIVATIVES AS CRAC MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-03-31 | — | — | WO | disclosed |
| WO-2010001166-A1 | THIAZOLE DERIVATIVES AS GPR 119 MODULATORS | PROSIDION LIMITED (GB) | 2010-01-07 | — | — | WO | disclosed |