Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6270712 | 0.78 | L3MBTL1 (0.34) | MAPK1KDM4EMAPT | |
| SCHEMBL6225316 | 0.76 | MAPK1 (0.30) | MAPK1 | |
| SCHEMBL8135029 | 0.74 | GABRA1 (0.33) | MAPK1 | |
| SCHEMBL1459947 | 0.74 | MAPK1 (0.34) | MAPK1 | |
| SCHEMBL8137468 | 0.72 | MAPK1 (0.33) | MAPK1 | |
| SCHEMBL29654701 | 0.70 | P2RX7 (0.34) | MAPK1 | |
| SCHEMBL31334613 | 0.69 | RORC (0.37) | MAPK1 | |
| SCHEMBL4427892 | 0.68 | CRBN (0.34) | MAPK1KDM4E | |
| SCHEMBL12216450 | 0.68 | NFKB1 (0.36) | MAPK1GAAKDM4EMAPT | |
| SCHEMBL2783077 | 0.67 | MAPK1 (0.35) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1292576-A1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY | Darwin Discovery Limited (GB) | 2003-03-19 | — | — | EP | disclosed |
| WO-2001087844-A1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY | DARWIN DISCOVERY LIMITED (GB) | 2001-11-22 | — | — | WO | disclosed |