Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14600777 | 0.92 | GSK3B (0.53) | MEN1KMT2ARAB9ANPC1HPGD | |
| SCHEMBL14600753 | 0.87 | GSK3B (0.53) | MEN1KMT2ARAB9ANPC1HPGD | |
| SCHEMBL14278769 | 0.77 | GSK3B (0.55) | MEN1KMT2ARAB9ANPC1HPGD | |
| SCHEMBL14286127 | 0.74 | GSK3B (0.56) | MEN1KMT2ARAB9ANPC1HPGD | |
| SCHEMBL14600773 | 0.73 | RAB9A (0.47) | MEN1KMT2ARAB9ANPC1HPGD | |
| SCHEMBL10067976 | 0.73 | GSK3B (0.44) | MEN1KMT2ARAB9ANPC1HPGD | |
| SCHEMBL10067975 | 0.73 | ALDH1A1 (0.46) | MEN1KMT2ARAB9ANPC1HPGD | |
| SCHEMBL14600763 | 0.73 | GSK3B (0.44) | MEN1KMT2ARAB9ANPC1HPGD | |
| SCHEMBL14600774 | 0.73 | GSK3B (0.45) | MEN1KMT2ARAB9ANPC1HPGD | |
| SCHEMBL10067977 | 0.73 | GSK3B (0.47) | MEN1KMT2ARAB9ANPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7169800-B2 | Imidazole compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-01-30 | — | — | US | disclosed |