Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.46 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14601555 | 0.85 | MAPT (0.51) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL11027332 | 0.84 | ALDH1A1 (0.58) | MAPTHTTSMN1; SMN2ALDH1A1PKM | |
| SCHEMBL11027336 | 0.84 | ALDH1A1 (0.58) | MAPTHTTSMN1; SMN2ALDH1A1PKM | |
| SCHEMBL29098724 | 0.82 | MAPT (0.52) | MAPTHCAR2TTRDPP4CA12 | |
| SCHEMBL28789132 | 0.81 | ALDH1A1 (0.68) | MAPTHCAR2CA12CA1CA2 | |
| SCHEMBL14601551 | 0.81 | ALDH1A1 (0.68) | MAPTHCAR2CA12CA1CA2 | |
| SCHEMBL14601550 | 0.80 | NPSR1 (0.52) | MAPTSMN1; SMN2ALDH1A1NPSR1LMNA | |
| SCHEMBL5166792 | 0.80 | MAPT (0.62) | MAPTALDH1A1ATMNPSR1LMNA | |
| SCHEMBL5166787 | 0.80 | MAPT (0.62) | MAPTALDH1A1ATMNPSR1LMNA | |
| SCHEMBL10920916 | 0.80 | CA12 (0.63) | MAPTHCAR2TTRDPP4CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7161022-B2 | Process for producing 4-phenyl-4-oxo-2-butenoic ester derivative | FUJIFILM FINECHEMICALS CO., LTD. (JP) | 2007-01-09 | — | — | US | disclosed |
| US-7161022-B2 | Process for producing 4-phenyl-4-oxo-2-butenoic ester derivative | FUJIFILM FINECHEMICALS CO., LTD. (JP) | 2007-01-09 | — | — | US | disclosed |