Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.60 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.56 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.56 |
| ▸ | FDPS | P14324 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5166787 | 1.00 | MAPT (0.62) | MAPTKDM4EABCG2LMNANPC1 | |
| SCHEMBL14601555 | 0.90 | MAPT (0.51) | MAPTKDM4EABCG2LMNANPC1 | |
| SCHEMBL14601550 | 0.85 | NPSR1 (0.52) | MAPTKDM4ELMNANPC1ALDH1A1 | |
| SCHEMBL5515523 | 0.84 | ABCG2 (0.67) | MAPTKDM4EABCG2LMNANPC1 | |
| SCHEMBL5515521 | 0.84 | ABCG2 (0.67) | MAPTKDM4EABCG2LMNANPC1 | |
| SCHEMBL9578915 | 0.80 | MAPT (0.59) | MAPTLMNANPC1MEN1KMT2A | |
| SCHEMBL29098731 | 0.80 | MAPT (0.59) | MAPTLMNANPC1MEN1KMT2A | |
| SCHEMBL14601554 | 0.80 | MAPT (0.48) | MAPTLMNANPC1MEN1KMT2A | |
| SCHEMBL5585542 | 0.80 | ABCG2 (0.69) | MAPTKDM4EABCG2LMNANPC1 | |
| SCHEMBL5585560 | 0.80 | ABCG2 (0.69) | MAPTKDM4EABCG2LMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108658765-B | Preparation method of 4- (3, 4-dimethoxyphenyl) -4-oxo-2-ethyl crotonate | 黄石市利福达医药化工有限公司 | 2021-03-16 | — | — | CN | claimed |
| US-4562068-A | Sebosuppressive cosmetic preparations containing aryloxobutenoic acid derivatives | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1985-12-31 | — | — | US | claimed |
| EP-0101918-A1 | Use of arylketobutenoic-acid derivatives, as component in cosmetic agents as well as arylketobutenoic-acid derivatives | Henkel Kommanditgesellschaft auf Aktien (DE) | 1984-03-07 | — | — | EP | claimed |
| CN-108658765-B | Preparation method of 4- (3, 4-dimethoxyphenyl) -4-oxo-2-ethyl crotonate | 黄石市利福达医药化工有限公司 | 2021-03-16 | — | — | CN | disclosed |
| CN-108658765-A | A kind of 4-（3,4- Dimethoxyphenyls）The preparation method of -4- oxo -2- butenoic acid ethyls | 黄石市利福达医药化工有限公司 | 2018-10-16 | — | — | CN | disclosed |
| US-7238812-B2 | Tricyclic triazolobenzazepine derivatives, process for producing the same, and antiallergic agents | MEJI SEIKA KAISHA, LTD. (JP) | 2007-07-03 | — | — | US | disclosed |
| US-7238719-B2 | Process for producing 1,2,3-Triazole compounds | MEIJI SEIKA KAISHA, LTD. (JP) | 2007-07-03 | — | — | US | disclosed |
| EP-1471058-B1 | PROCESS FOR PRODUCING 1,2,3-TRIAZOLE COMPOUND | MEIJI SEIKA KAISHA (JP) | 2007-04-11 | — | — | EP | disclosed |
| US-20060074074-A1 | Tricyclic triazolobenzazepine derivatives, process for producing the same, and antiallergic agents | MEIJI SEIKA PHARMA CO., LTD. (JP) | 2006-04-06 | — | — | US | disclosed |
| US-7022860-B2 | Tricyclic triazolobenzazepine derivatives, process for producing the same, and antiallergic agents | MEIJI SEIKA KAISHA, LTD. (JP) | 2006-04-04 | — | — | US | disclosed |
| US-20050080270-A1 | Process for producing 1 2 3 triazole compound | MEIJI SEIKA PHARMA CO., LTD. (JP) | 2005-04-14 | — | — | US | disclosed |
| EP-1471058-A1 | PROCESS FOR PRODUCING 1,2,3-TRIAZOLE COMPOUND | MEIJI SEIKA KAISHA LTD. (JP) | 2004-10-27 | — | — | EP | disclosed |
| EP-1026167-B1 | TRICYCLIC TRIAZOLOBENZAZEPINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND ANTIALLERGIC AGENTS | MEIJI SEIKA KAISHA (JP) | 2003-03-05 | — | — | EP | disclosed |
| US-20020137739-A1 | Tricyclic triazolobenzazepine derivatives, process for producing the same, and antiallergic agents | MEIJI SEIKA PHARMA CO., LTD. (JP) | 2002-09-26 | — | — | US | disclosed |
| US-6372735-B1 | ANTIHISTAMINES | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-04-16 | — | — | US | disclosed |
| EP-1026167-A1 | TRICYCLIC TRIAZOLOBENZAZEPINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND ANTIALLERGIC | MEIJI SEIKA KAISHA LTD. (JP) | 2000-08-09 | — | — | EP | disclosed |
| US-4562068-A | Sebosuppressive cosmetic preparations containing aryloxobutenoic acid derivatives | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1985-12-31 | — | — | US | disclosed |
| EP-0101918-A1 | Use of arylketobutenoic-acid derivatives, as component in cosmetic agents as well as arylketobutenoic-acid derivatives | Henkel Kommanditgesellschaft auf Aktien (DE) | 1984-03-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050080270-A1 | Process for producing 1 2 3 triazole compound | RPS27L, KARS1, STK38L | MAPT 4274/4885KDM4E 2894/4885ABCG2 1442/4885 |
| US-20060074074-A1 | Tricyclic triazolobenzazepine derivatives, process for producing the same, and antiallergic agents | HRH4, CYP2D6, CYP2B6 | MAPT 3031/4885KDM4E 752/4885ABCG2 49/4885 |
| US-20020137739-A1 | Tricyclic triazolobenzazepine derivatives, process for producing the same, and antiallergic agents | HRH4, CYP3A4, TPH1 | MAPT 3223/4885KDM4E 547/4885ABCG2 38/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.