SCHEMBL1460367

SCHEMBL1460367

NC(=O)c1ccc(C(N)=O)c(-c2cccc3ccccc23)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.46
ALDH1A1 P00352 2/20 0.46
GAA P10253 2/20 0.46
HDAC8 Q9BY41 1/20 0.44
HDAC6 Q9UBN7 1/20 0.44
PARP10 Q53GL7 1/20 0.43
PARP1 P09874 1/20 0.43
POLB P06746 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
PTPN1 P18031 1/20 0.43
CDC7 O00311 1/20 0.43
ALOX5 P09917 1/20 0.43
KMT2A Q03164 3/20 0.42
MEN1 O00255 2/20 0.42
MCL1 Q07820 1/20 0.42
ACMSD Q8TDX5 1/20 0.42
BCAT2 O15382 1/20 0.42
PDK2 Q15119 1/20 0.41
HPGD P15428 1/20 0.41
SIRT2 Q8IXJ6 3/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28013892 0.84 BTK (0.43) KDM4EALDH1A1PARP10PARP1BCAT2
SCHEMBL30892682 0.83 BCAT2 (0.55) KDM4EALDH1A1GAAHDAC8PARP1
SCHEMBL5849850 0.83 BCAT2 (0.55) KDM4EALDH1A1GAAHDAC8PARP1
SCHEMBL31621277 0.83 BCAT2 (0.55) KDM4EALDH1A1GAAHDAC8PARP1
SCHEMBL27597015 0.81 KEAP1 (0.47) KDM4EALDH1A1GAAPARP10PARP1
SCHEMBL22411053 0.80 PARP1 (0.46) KDM4EALDH1A1GAAPARP10PARP1
Water SCHEMBL27919080 0.79 KEAP1 (0.46) KDM4EALDH1A1GAAPARP10PARP1
SCHEMBL250471 0.79 HSD17B10 (0.56) KDM4EALDH1A1HDAC8HDAC6PTPN1
SCHEMBL27621512 0.79 BTK (0.50) ALDH1A1PARP1POLBKMT2AMEN1
SCHEMBL9630211 0.78 HDAC8 (0.44) KDM4EALDH1A1GAAHDAC8HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2486229-A2 APPARATUSES AND METHODS OF MANUFACTURING OILFIELD MACHINES M.I L.L, C. (US) 2012-08-15 EP disclosed
WO-2011044227-A2 APPARATUSES AND METHODS OF MANUFACTURING OILFIELD MACHINES M-I L.L.C. (US) 2011-04-14 WO disclosed
WO-2011028746-A1 LIGHTWEIGHT, CUT AND/OR ABRASION RESISTANT GARMENTS, AND RELATED PROTECTIVE WEAR KOLMES NATHANIEL H (US) 2011-03-10 WO disclosed
WO-2002077070-A1 CONDUCTIVE POLYMERS SUBSTITUTED WITH ACID LABILE FUNCTIONAL GROUPS FOR INCREASING ELECTRICAL CONDUCTIVITY AND PATTERNABILITY AND COMPOSITIONS HAVING THE SAME PARA LIMITED (KR) 2002-10-03 WO disclosed
EP-0927330-A1 BLAST RESISTANT AND BLAST DIRECTING CONTAINER ASSEMBLIES AlliedSignal Inc. (US) 1999-07-07 EP disclosed
EP-0852695-A1 BLAST RESISTANT AND BLAST DIRECTING CONTAINERS AND METHODS OF MAKING AlliedSignal Inc. (US) 1998-07-15 EP disclosed
WO-1998012496-A1 BLAST RESISTANT AND BLAST DIRECTING CONTAINER ASSEMBLIES ALLIEDSIGNAL INC. (US) 1998-03-26 WO disclosed
WO-1997012195-A1 BLAST RESISTANT AND BLAST DIRECTING CONTAINERS AND METHODS OF MAKING ALLIEDSIGNAL INC. (US) 1997-04-03 WO disclosed
EP-0685058-A1 COMPOSITES HAVING IMPROVED PENETRATION RESISTANCE AlliedSignal Inc. (US) 1995-12-06 EP disclosed
WO-1994019660-A1 COMPOSITES HAVING IMPROVED PENETRATION RESISTANCE ALLIEDSIGNAL INC. (US) 1994-09-01 WO disclosed
EP-0510093-A1 CUT RESISTANT PROTECTIVE GLOVE. ALLIED SIGNAL INC (US) 1992-10-28 EP disclosed
WO-1991010409-A1 CUT RESISTANT PROTECTIVE GLOVE ALLIED-SIGNAL INC. (US) 1991-07-25 WO disclosed