Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | ITK | Q08881 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 3/20 | 0.35 |
| ▸ | RORC | P51449 | 2/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | GRK6 | P43250 | 1/20 | 0.34 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.33 |
| ▸ | GPR6 | P46095 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | PAK4 | O96013 | 1/20 | 0.33 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5591240 | 0.90 | RET (0.40) | LCKITKAURKBRETGRIA2 | |
| SCHEMBL14605910 | 0.89 | AURKB (0.39) | LCKITKAURKBRETAURKA | |
| SCHEMBL14605903 | 0.84 | PAK1 (0.38) | LCKITKAURKBRETGRIA2 | |
| SCHEMBL14605943 | 0.83 | PLK4 (0.38) | LCKITKAURKBRETGRIA2 | |
| SCHEMBL14605897 | 0.79 | LCK (0.56) | LCKITKAURKBRETPAK4 | |
| SCHEMBL5591517 | 0.74 | GRK6 (0.42) | GRIA2GRIN1GRIN2AAURKAGRK6 | |
| SCHEMBL14605970 | 0.72 | LCK (0.57) | LCKITKAURKBRETPLK4 | |
| SCHEMBL14605945 | 0.71 | LCK (0.45) | LCKITKAURKBRETPLK4 | |
| SCHEMBL14605960 | 0.68 | LCK (0.50) | LCKITKAURKBRETAURKA | |
| SCHEMBL14606097 | 0.67 | LCK (0.48) | LCKITKAURKBRETAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007023382-A2 | PYRIMIDINE AMINO PYRAZOLE COMPOUNDS, POTENT KINASE INHIBITORS | PFIZER INC. (US) | 2007-03-01 | — | — | WO | disclosed |