Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 10/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 9/20 | 0.45 |
| ▸ | TSHR | P16473 | 6/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | GLA | P06280 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14606873 | 0.88 | PDE10A (0.49) | PDE10AADRA2ANPY5RCYP2D6CYP1A2 | |
| SCHEMBL14606597 | 0.78 | ADRA2A (0.73) | PDE10AADRA2ANPY5RALDH1A1MAPT | |
| SCHEMBL13794892 | 0.76 | ALDH1A1 (0.47) | ADRA2ANPY5RCYP2D6CYP1A2TSHR | |
| SCHEMBL15457190 | 0.75 | SMN1; SMN2 (0.56) | PDE10ACYP2D6CYP1A2TSHRCYP2C19 | |
| SCHEMBL13795182 | 0.74 | MCHR1 (0.38) | PDE10AADRA2ANPY5RCYP2D6CYP1A2 | |
| SCHEMBL638079 | 0.73 | SMN1; SMN2 (0.54) | PDE10ACYP2D6CYP1A2TSHRCYP2C19 | |
| SCHEMBL2178309 | 0.73 | SMN1; SMN2 (0.58) | PDE10ACYP2D6CYP1A2TSHRCYP2C19 | |
| SCHEMBL14606600 | 0.73 | MCHR1 (0.62) | ADRA2ANPY5RMCHR1 | |
| SCHEMBL12409984 | 0.72 | SMN1; SMN2 (0.53) | PDE10ACYP2D6CYP1A2TSHRCYP2C19 | |
| SCHEMBL13795669 | 0.71 | MCHR1 (0.54) | ADRA2ANPY5RMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070037836-A1 | Melanin concentrating hormone; obesity and related disorders, anxiety, or depression; trans-4-Bromo-N-{4-[(4-dimethylamino-quinazolin-2-ylamino)-methyl]-cyclohexylmethyl}-2-trifluoromethoxy-benzenesulfonamide | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2007-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070037836-A1 | Melanin concentrating hormone; obesity and related disorders, anxiety, or depression; trans-4-Bromo-N-{4-[(4-dimethylamino-quinazolin-2-ylamino)-methyl]-cyclohexylmethyl}-2-trifluoromethoxy-benzenesulfonamide | MCHR1, MCHR2, MC4R | PDE10A 1346/4885ADRA2A 131/4885NPY5R 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.