Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3117290 | 0.89 | TRPV1 (0.47) | KDM5AKDM2BKDM4CMAPTKMT2A | |
| SCHEMBL3109283 | 0.78 | PTPN1 (0.51) | KDM5AKDM2BKDM4CMAPTKMT2A | |
| SCHEMBL13248896 | 0.78 | ALDH1A1 (0.47) | MAPTKMT2AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL3107074 | 0.77 | CYP11B1 (0.46) | KDM5AKDM2BKDM4CMAPTKMT2A | |
| SCHEMBL3116564 | 0.77 | PTPN1 (0.50) | KDM5AKDM2BKDM4CMAPTKMT2A | |
| SCHEMBL3117708 | 0.71 | KCNQ3 (0.56) | MAPTKMT2AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL3117351 | 0.71 | BRAF (0.50) | MAPTKDM4E | |
| SCHEMBL3121975 | 0.69 | P4HTM (0.52) | MAPTKMT2AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL3112527 | 0.69 | RAB9A (0.55) | MAPTKMT2AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL3117426 | 0.69 | ORAI1 (0.60) | MAPTKMT2AALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007020426-A1 | PYRAZOLONE DERIVATIVES FOR THE TREATMENT OF TUBERCULOSIS | ASTRAZENECA AB (SE) | 2007-02-22 | — | — | WO | disclosed |