Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 2/20 | 0.56 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.56 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.56 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 6/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.47 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3109283 | 0.89 | PTPN1 (0.51) | KCNQ3KCNQ2KCNE1KCNQ1RAB9A | |
| SCHEMBL3116564 | 0.88 | PTPN1 (0.50) | KCNQ3KCNQ2RAB9AALDH1A1NPC1 | |
| SCHEMBL14609473 | 0.88 | ULK1 (0.47) | KCNQ3KCNQ2KCNE1KCNQ1ALDH1A1 | |
| SCHEMBL3117426 | 0.86 | ORAI1 (0.60) | RAB9AALDH1A1NPC1KDM4EMEN1 | |
| SCHEMBL3117351 | 0.85 | BRAF (0.50) | KDM4EBRAFMAPT | |
| SCHEMBL3120279 | 0.84 | RAB9A (0.57) | RAB9AALDH1A1NPC1KDM4EMEN1 | |
| SCHEMBL3117348 | 0.82 | SMN1; SMN2 (0.58) | KCNQ3KCNQ2KCNE1KCNQ1RAB9A | |
| SCHEMBL3121975 | 0.82 | P4HTM (0.52) | RAB9AALDH1A1NPC1KDM4EMEN1 | |
| SCHEMBL3117290 | 0.81 | TRPV1 (0.47) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL3116048 | 0.80 | P4HTM (0.54) | RAB9AALDH1A1NPC1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100179161-A1 | PYRAZOLINE DERIVATIVES FOR THE TREATMENT OF TURBERCULOSIS | ASTRAZENECA AB (SE) | 2010-07-15 | — | — | US | disclosed |
| US-20100179161-A1 | PYRAZOLINE DERIVATIVES FOR THE TREATMENT OF TURBERCULOSIS | ASTRAZENECA AB (SE) | 2010-07-15 | — | — | US | disclosed |
| US-20100179161-A1 | PYRAZOLINE DERIVATIVES FOR THE TREATMENT OF TURBERCULOSIS | ASTRAZENECA AB (SE) | 2010-07-15 | — | — | US | disclosed |
| US-20100179153-A1 | Bicyclic S1P Receptor Modulators | NOVARTIS AG (CH) | 2010-07-15 | — | — | US | disclosed |
| CN-101291923-A | Pyrazolone derivatives for the treatment of tuberculosis | ASTRAZENECA AB (SE) | 2008-10-22 | — | — | CN | disclosed |
| EP-1919890-A1 | PYRAZOLONE DERIVATIVES FOR THE TREATMENT OF TUBERCULOSIS | AstraZeneca AB (SE) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007020426-A1 | PYRAZOLONE DERIVATIVES FOR THE TREATMENT OF TUBERCULOSIS | ASTRAZENECA AB (SE) | 2007-02-22 | — | — | WO | disclosed |
| WO-2007020426-A1 | PYRAZOLONE DERIVATIVES FOR THE TREATMENT OF TUBERCULOSIS | ASTRAZENECA AB (SE) | 2007-02-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179153-A1 | Bicyclic S1P Receptor Modulators | S1PR1, S1PR2, S1PR5 | KCNQ3 1415/4885KCNQ2 1326/4885KCNE1 1026/4885 |
| US-20100179161-A1 | PYRAZOLINE DERIVATIVES FOR THE TREATMENT OF TURBERCULOSIS | TREH, TYMP, EPX | KCNQ3 2202/4885KCNQ2 2304/4885KCNE1 3095/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.