Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7527557 | 0.81 | MAPT (0.50) | MAPTALDH1A1KMT2APOLBTSHR | |
| SCHEMBL432006 | 0.70 | MAPT (0.54) | MAPTALDH1A1KMT2APOLBTSHR | |
| SCHEMBL24421946 | 0.69 | MAPT (0.47) | MAPTALDH1A1KMT2APOLBKDM4E | |
| SCHEMBL368265 | 0.67 | MAPT (0.56) | MAPTALDH1A1KMT2APOLBTSHR | |
| SCHEMBL11101159 | 0.67 | MAOA (0.41) | MAPTALDH1A1POLBTSHRKDM4E | |
| SCHEMBL305185 | 0.65 | MAPT (0.54) | MAPTALDH1A1KMT2APOLBTSHR | |
| SCHEMBL20036958 | 0.65 | MAPT (0.54) | MAPTALDH1A1KMT2APOLBTSHR | |
| SCHEMBL9348170 | 0.65 | MAPT (0.54) | MAPTALDH1A1KMT2APOLBTSHR | |
| SCHEMBL27498457 | 0.65 | MAPT (0.54) | MAPTALDH1A1KMT2APOLBTSHR | |
| Bromide SCHEMBL3997504 | 0.64 | MAPT (0.52) | MAPTALDH1A1KMT2APOLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2475643-A1 | NOVEL ETHANE DIAMINE HEPCIDIN ANTAGONISTS | VIFOR (INTERNATIONAL) AG (CH) | 2012-07-18 | — | — | EP | disclosed |
| WO-2011026959-A1 | NOVEL ETHANE DIAMINE HEPCIDIN ANTAGONISTS | VIFOR (INTERNATIONAL) AG (CH) | 2011-03-10 | — | — | WO | disclosed |
| US-4432984-A | Anti-hypertensive benzodioxan derivatives | Bouchara, Emile (FR) | 1984-02-21 | — | — | US | disclosed |