Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.68 |
| ▸ | NR1I2 | O75469 | 9/20 | 0.65 |
| ▸ | RORC | P51449 | 9/20 | 0.55 |
| ▸ | NR1H2 | P55055 | 8/20 | 0.53 |
| ▸ | RORA | P35398 | 3/20 | 0.52 |
| ▸ | RORB | Q92753 | 3/20 | 0.52 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.52 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | RXRA | P19793 | 1/20 | 0.52 |
| ▸ | SREBF1 | P36956 | 1/20 | 0.52 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.52 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.52 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.52 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.52 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.52 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.52 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5564186 | 0.91 | HSD11B1 (0.83) | HSD11B1NR1I2RORCNR1H2RORA | |
| SCHEMBL14613670 | 0.90 | HSD11B1 (0.82) | HSD11B1NR1I2RORCNR1H2RORA | |
| SCHEMBL5564305 | 0.81 | HSD11B1 (1.00) | HSD11B1NR1I2RORCNR1H2RORA | |
| SCHEMBL14613566 | 0.76 | HSD11B1 (0.61) | HSD11B1NR1I2RORCNR1H2RORA | |
| SCHEMBL5564300 | 0.72 | HSD11B1 (0.76) | HSD11B1NR1I2RORCNR1H2 | |
| SCHEMBL5564561 | 0.71 | HSD11B1 (1.00) | HSD11B1 | |
| SCHEMBL5564297 | 0.71 | HSD11B1 (1.00) | HSD11B1 | |
| SCHEMBL5564290 | 0.71 | HSD11B1 (1.00) | HSD11B1 | |
| SCHEMBL4611779 | 0.70 | HSD11B1 (0.80) | HSD11B1NR1I2RORCNR1H2RORA | |
| SCHEMBL16063605 | 0.70 | RORC (0.86) | NR1I2RORCNR1H2RORARORB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007013929-A1 | ANILINE SULFONAMIDE DERIVATIVES AND THEIR USES | AMGEN INC. (US) | 2007-02-01 | — | — | WO | disclosed |