Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAL | P20701 | 3/20 | 0.53 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.53 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.53 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | PYGL | P06737 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HPGDS | O60760 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14613998 | 0.89 | ITGB2 (0.52) | ITGALITGB2ICAM1MRGPRX4CA2 | |
| SCHEMBL16286275 | 0.82 | CA2 (0.48) | ITGALITGB2ICAM1MRGPRX4CA2 | |
| SCHEMBL15507458 | 0.82 | CA2 (0.48) | ITGALITGB2ICAM1MRGPRX4CA2 | |
| SCHEMBL16286274 | 0.82 | CA2 (0.48) | ITGALITGB2ICAM1MRGPRX4CA2 | |
| SCHEMBL3871439 | 0.82 | ITGAL (0.51) | ITGALITGB2ICAM1RAB9AALDH1A1 | |
| SCHEMBL14614282 | 0.81 | ITGAL (0.55) | ITGALITGB2ICAM1MRGPRX4CA2 | |
| SCHEMBL3866996 | 0.79 | ROCK2 (0.45) | ITGALITGB2ICAM1RAB9AMEN1 | |
| SCHEMBL14613923 | 0.79 | ITGAL (0.67) | ITGALITGB2ICAM1MRGPRX4CA2 | |
| SCHEMBL30227636 | 0.78 | ITGAL (0.51) | ITGALITGB2ICAM1RAB9AMEN1 | |
| SCHEMBL16286432 | 0.78 | ITGAL (0.51) | ITGALITGB2ICAM1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1754705-A2 | Antagonists for treatment of CD11/CD18 adhesion receptor mediated disorders | Genentech, Inc. (US) | 2007-02-21 | — | — | EP | disclosed |