Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAL | P20701 | 3/20 | 0.54 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.54 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.54 |
| ▸ | ITGB1 | P05556 | 11/20 | 0.47 |
| ▸ | ITGA5 | P08648 | 10/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | PYGL | P06737 | 2/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.40 |
| ▸ | ITGAV | P06756 | 2/20 | 0.40 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14613756 | 0.97 | ITGAL (0.53) | ITGALITGB2ICAM1ITGB1ITGA5 | |
| SCHEMBL14614003 | 0.85 | ITGAL (0.51) | ITGALITGB2ICAM1ITGB1ITGA5 | |
| SCHEMBL14614046 | 0.79 | HTT (0.47) | ITGB1ITGA5CA1CA2MEN1 | |
| SCHEMBL14614282 | 0.78 | ITGAL (0.55) | ITGALITGB2ICAM1ITGB1ITGA5 | |
| SCHEMBL14614020 | 0.76 | ITGAL (0.53) | ITGALITGB2ICAM1ITGB1ITGA5 | |
| SCHEMBL14613923 | 0.76 | ITGAL (0.67) | ITGALITGB2ICAM1ITGB1ITGA5 | |
| SCHEMBL14614082 | 0.75 | PYGL (0.45) | ITGALITGB2ICAM1ITGB1ITGA5 | |
| SCHEMBL14614312 | 0.75 | ITGAL (0.56) | ITGALITGB2ICAM1ITGB1ITGA5 | |
| SCHEMBL14614314 | 0.75 | ITGAL (0.52) | ITGALITGB2ICAM1ITGB1ITGA5 | |
| SCHEMBL14614311 | 0.74 | ITGAL (0.48) | ITGALITGB2ICAM1ITGB1ITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1754705-A2 | Antagonists for treatment of CD11/CD18 adhesion receptor mediated disorders | Genentech, Inc. (US) | 2007-02-21 | — | — | EP | disclosed |
| EP-1063982-B1 | ANTAGONISTS FOR TREATMENT OF CD11/CD18 ADHESION RECEPTOR MEDIATED DISORDERS | GENENTECH INC (US) | 2007-02-14 | — | — | EP | disclosed |