Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.45 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | CPB1 | P15086 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HBB | P68871 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30009848 | 0.88 | AKR1C3 (0.47) | ACHEPLA2G1BATG4BKCNH2HTR2A | |
| SCHEMBL12050567 | 0.86 | ACHE (0.46) | ACHEPLA2G1BATG4BKCNH2HTR2A | |
| SCHEMBL30009761 | 0.84 | HTR2A (0.43) | KCNH2HTR2A | |
| SCHEMBL25740889 | 0.83 | ACHE (0.44) | ACHEKCNH2HTR2ACPB1MEN1 | |
| SCHEMBL25740890 | 0.83 | ACHE (0.44) | ACHEKCNH2HTR2ACPB1MEN1 | |
| SCHEMBL18681661 | 0.83 | ACHE (0.44) | ACHEKCNH2HTR2ACPB1MEN1 | |
| SCHEMBL8260835 | 0.82 | ACHE (0.53) | ACHEKCNH2HTR2ACPB1HTT | |
| SCHEMBL13176096 | 0.82 | ACHE (0.53) | ACHEKCNH2HTR2ACPB1HTT | |
| SCHEMBL30009684 | 0.80 | KMT2A (0.54) | MAPTHTTMEN1KMT2AMGLL | |
| SCHEMBL18428493 | 0.78 | HTR2A (0.56) | KCNH2HTR2ACPB1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023250439-A1 | TREX1 INHIBITORS AND USES THEREOF | TEMPEST THERAPEUTICS, INC. (US) | 2023-12-28 | — | — | WO | disclosed |