Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.44 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.44 |
| ▸ | PDE2A | O00408 | 2/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PTGER2 | P43116 | 4/20 | 0.40 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.40 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.40 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28439330 | 1.00 | HSD11B1 (0.44) | HSD11B1S1PR2S1PR1S1PR3LPAR2 | |
| SCHEMBL16366239 | 1.00 | HSD11B1 (0.44) | HSD11B1S1PR2S1PR1S1PR3LPAR2 | |
| SCHEMBL2277018 | 0.95 | KIF11 (0.42) | HSD11B1S1PR2S1PR1S1PR3LPAR2 | |
| SCHEMBL2267312 | 0.95 | KIF11 (0.42) | HSD11B1S1PR2S1PR1S1PR3LPAR2 | |
| SCHEMBL2274452 | 0.95 | KIF11 (0.42) | HSD11B1S1PR2S1PR1S1PR3LPAR2 | |
| SCHEMBL2274456 | 0.95 | KIF11 (0.42) | HSD11B1S1PR2S1PR1S1PR3LPAR2 | |
| SCHEMBL2274458 | 0.95 | KIF11 (0.42) | HSD11B1S1PR2S1PR1S1PR3LPAR2 | |
| SCHEMBL2277014 | 0.95 | KIF11 (0.42) | HSD11B1S1PR2S1PR1S1PR3LPAR2 | |
| SCHEMBL2268729 | 0.93 | KIF11 (0.43) | HSD11B1S1PR2S1PR1S1PR3LPAR2 | |
| SCHEMBL2268737 | 0.93 | KIF11 (0.43) | HSD11B1S1PR2S1PR1S1PR3LPAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070026441-A1 | Using humanized monoclonal antibody (POR140) as therapeutic to decrease viral particles in human immunodeficiency virus infected individuals; viricides; enzyme inhibitors | PROGENICS PHARMACEUTICALS, INC. | 2007-02-01 | — | — | US | disclosed |