Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.44 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.44 |
| ▸ | PDE2A | O00408 | 2/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PTGER2 | P43116 | 4/20 | 0.40 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.40 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.40 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14614552 | 1.00 | HSD11B1 (0.44) | HSD11B1S1PR2S1PR1S1PR3LPAR2 | |
| SCHEMBL28439330 | 1.00 | HSD11B1 (0.44) | HSD11B1S1PR2S1PR1S1PR3LPAR2 | |
| SCHEMBL2277018 | 0.95 | KIF11 (0.42) | HSD11B1S1PR2S1PR1S1PR3LPAR2 | |
| SCHEMBL2267312 | 0.95 | KIF11 (0.42) | HSD11B1S1PR2S1PR1S1PR3LPAR2 | |
| SCHEMBL2274452 | 0.95 | KIF11 (0.42) | HSD11B1S1PR2S1PR1S1PR3LPAR2 | |
| SCHEMBL2274456 | 0.95 | KIF11 (0.42) | HSD11B1S1PR2S1PR1S1PR3LPAR2 | |
| SCHEMBL2274458 | 0.95 | KIF11 (0.42) | HSD11B1S1PR2S1PR1S1PR3LPAR2 | |
| SCHEMBL2277014 | 0.95 | KIF11 (0.42) | HSD11B1S1PR2S1PR1S1PR3LPAR2 | |
| SCHEMBL2268729 | 0.93 | KIF11 (0.43) | HSD11B1S1PR2S1PR1S1PR3LPAR2 | |
| SCHEMBL2268737 | 0.93 | KIF11 (0.43) | HSD11B1S1PR2S1PR1S1PR3LPAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170049884-A1 | USE OF ANTI-CCR5 ANTIBODIES IN GRAFT VERSUS HOST DISEASE | CYTODYN INC. (US) | 2017-02-23 | — | — | US | disclosed |
| US-20140377259-A1 | METHODS FOR INHIBITING HIV-1 REPLICATION INVOLVING THE ADMINISTRATION OF AN ANTI-CCR5 RECEPTOR MONOCLONAL ANTIBODY AND SMALL MOLECULE CCR5 RECEPTOR ANTAGONIST | CYTODYN INC. | 2014-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140377259-A1 | METHODS FOR INHIBITING HIV-1 REPLICATION INVOLVING THE ADMINISTRATION OF AN ANTI-CCR5 RECEPTOR MONOCLONAL ANTIBODY AND SMALL MOLECULE CCR5 RECEPTOR ANTAGONIST | CD4, CCR5, HAVCR2 | HSD11B1 2223/4885S1PR2 351/4885S1PR1 123/4885 |
| US-20170049884-A1 | USE OF ANTI-CCR5 ANTIBODIES IN GRAFT VERSUS HOST DISEASE | CCR5, CD4, CCR10 | HSD11B1 2088/4885S1PR2 145/4885S1PR1 92/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.