Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Balsalazide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.52 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.52 |
| ▸ | NME4 | O00746 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.52 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.52 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.52 |
| ▸ | HTR3A | P46098 | 1/20 | 0.52 |
| ▸ | GCDH | Q92947 | 1/20 | 0.52 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | GABBR2 | O75899 | 3/20 | 0.44 |
| ▸ | GABBR1 | Q9UBS5 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Balsalazide SCHEMBL3667344 | 0.88 | SIRT5 (0.68) | ADORA3SIRT5NME4CHRM1ADORA2A | |
| Balsalazide SCHEMBL29383212 | 0.82 | SIRT5 (0.67) | ADORA3SIRT5NME4CHRM1ADORA2A | |
| Balsalazide SCHEMBL30360 | 0.82 | SIRT5 (0.67) | ADORA3SIRT5NME4CHRM1ADORA2A | |
| Balsalazide SCHEMBL30361 | 0.81 | SIRT5 (0.65) | ADORA3SIRT5NME4CHRM1ADORA2A | |
| Balsalazide SCHEMBL29352778 | 0.81 | SIRT5 (0.65) | ADORA3SIRT5NME4CHRM1ADORA2A | |
| SCHEMBL11168262 | 0.73 | TDP1 (0.61) | ADORA3SIRT5NME4CHRM1ADORA2A | |
| Balsalazide SCHEMBL3267109 | 0.70 | SIRT5 (1.00) | ADORA3SIRT5NME4CHRM1ADORA2A | |
| Balsalazide SCHEMBL138311 | 0.70 | SIRT5 (1.00) | ADORA3SIRT5NME4CHRM1ADORA2A | |
| Balsalazide SCHEMBL118300 | 0.70 | SIRT5 (1.00) | ADORA3SIRT5NME4CHRM1ADORA2A | |
| Balsalazide SCHEMBL29377041 | 0.70 | SIRT5 (1.00) | ADORA3SIRT5NME4CHRM1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2494075-A2 | TEMPLATED NANOCONJUGATES | Northwestern University (US) | 2012-09-05 | — | — | EP | disclosed |
| EP-2473160-A1 | DELIVERY OF THERAPEUTIC AGENTS USING OLIGONUCLEOTIDE-MODIFIED NANOPARTICLES AS CARRIERS | Northwestern University (US) | 2012-07-11 | — | — | EP | disclosed |
| WO-2011053940-A2 | TEMPLATED NANOCONJUGATES | NORTHWESTERN UNIVERSITY (US) | 2011-05-05 | — | — | WO | disclosed |
| WO-2011028850-A1 | DELIVERY OF THERAPEUTIC AGENTS USING OLIGONUCLEOTIDE-MODIFIED NANOPARTICLES AS CARRIERS | NORTHWESTERN UNIVERSITY (US) | 2011-03-10 | — | — | WO | disclosed |