Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 2/20 | 0.46 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | EP300 | Q09472 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30279574 | 0.78 | HTR7 (0.51) | ALDH1A1ADRA2BPTGS1TDP1L3MBTL1 | |
| SCHEMBL5565297 | 0.76 | ALDH1A1 (0.41) | PDCD1CD274ALDH1A1ADRA2BPTGS1 | |
| SCHEMBL15624701 | 0.74 | PDE4A (0.52) | PDCD1CD274ALDH1A1TDP1L3MBTL1 | |
| SCHEMBL4069438 | 0.73 | POLB (0.50) | ALDH1A1ADRA2BPTGS1TDP1L3MBTL1 | |
| SCHEMBL395260 | 0.72 | ALDH1A1 (0.67) | ALDH1A1ADRA2BPTGS1TDP1L3MBTL1 | |
| SCHEMBL3794284 | 0.72 | ALDH1A1 (0.59) | PDCD1CD274ALDH1A1L3MBTL1IDO1 | |
| SCHEMBL3787198 | 0.71 | ALDH1A1 (0.50) | ALDH1A1ADRA2BPTGS1TDP1L3MBTL1 | |
| SCHEMBL3790445 | 0.71 | ALDH1A1 (0.50) | ALDH1A1ADRA2BPTGS1TDP1L3MBTL1 | |
| SCHEMBL95746 | 0.71 | PDE4A (0.64) | PDCD1CD274ALDH1A1TDP1L3MBTL1 | |
| SCHEMBL16156475 | 0.71 | PDE4A (0.62) | PDCD1CD274FGFR1SRCPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7173129-B2 | Sulfonamide-substituted chalcone derivatives and their use to treat diseases | ATHERO GENICS, INC. (US) | 2007-02-06 | — | — | US | disclosed |