SCHEMBL14616505

SCHEMBL14616505

CC(=O)Cc1cc(-c2ccc(Cl)cc2)c(C)cc1C

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SUCNR1 Q9BXA5 2/20 0.43
SLC1A3 P43003 1/20 0.40
SLC1A2 P43004 1/20 0.40
SLC1A1 P43005 1/20 0.40
HSD17B1 P14061 1/20 0.40
ALDH1A1 P00352 2/20 0.38
PTGDR2 Q9Y5Y4 2/20 0.38
KDM4E B2RXH2 2/20 0.38
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
RAB9A P51151 4/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
MAPT P10636 1/20 0.37
RXRA P19793 1/20 0.36
RXRB P28702 1/20 0.36
RXRG P48443 1/20 0.36
SLC6A4 P31645 1/20 0.36
SLC6A3 Q01959 1/20 0.36
NPC1 O15118 3/20 0.35
AURKA O14965 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2352721 0.88 SUCNR1 (0.54) SUCNR1SLC1A3SLC1A2SLC1A1ALDH1A1
SCHEMBL14089365 0.84 SUCNR1 (0.43) SUCNR1SLC1A3SLC1A2SLC1A1ALDH1A1
SCHEMBL7102760 0.83 SUCNR1 (0.43) SUCNR1SLC1A3SLC1A2SLC1A1HSD17B1
SCHEMBL14089362 0.81 SUCNR1 (0.40) SUCNR1SLC1A3SLC1A2SLC1A1ALDH1A1
SCHEMBL7103710 0.78 SUCNR1 (0.43) SUCNR1SLC1A3SLC1A2SLC1A1ALDH1A1
SCHEMBL25899790 0.76 GAA (0.42) ALDH1A1PTGDR2MEN1KMT2ASMN1; SMN2
SCHEMBL16527178 0.73 CYP3A4 (0.45) ALDH1A1MAPTRXRARXRBRXRG
SCHEMBL14616506 0.72 PTGDR2 (0.38) SUCNR1SLC1A3SLC1A2SLC1A1ALDH1A1
SCHEMBL2355633 0.71 SHMT1 (0.41) SUCNR1SLC1A3SLC1A2SLC1A1ALDH1A1
SCHEMBL14616507 0.71 PTGDR2 (0.38) ALDH1A1PTGDR2KDM4EMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130018202-A1 4-Biphenyl-Substituted Pyrazolidin-3,5-Dione Derivatives BAYER CROPSCIENCE AG (DE) 2013-01-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130018202-A1 4-Biphenyl-Substituted Pyrazolidin-3,5-Dione Derivatives DDT, CYP4X1, HPD SUCNR1 3595/4885SLC1A3 4136/4885SLC1A2 3821/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.