Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | SETDB1 | Q15047 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.39 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3632865 | 0.85 | KEAP1 (0.50) | GAAPOLBMRGPRX4MAPTSMN1; SMN2 | |
| SCHEMBL14263482 | 0.82 | LMNA (0.44) | POLBLMNAALDH1A1CYP3A4P2RX7 | |
| SCHEMBL9939701 | 0.81 | ANO1 (0.43) | MRGPRX4LMNAALDH1A1CYP3A4SETDB1 | |
| SCHEMBL16273861 | 0.81 | CYP3A4 (0.41) | GAAPOLBMRGPRX4LMNAALDH1A1 | |
| SCHEMBL13136741 | 0.80 | ALDH1A1 (0.49) | GAAPOLBMRGPRX4LMNAALDH1A1 | |
| SCHEMBL9969945 | 0.80 | TAAR1 (0.48) | GAAPOLBCYP3A4TSHRHTT | |
| SCHEMBL13136742 | 0.80 | MTNR1A (0.44) | MRGPRX4LMNAALDH1A1HTTUSP2 | |
| SCHEMBL28684824 | 0.79 | NOS3 (0.40) | GAALMNAALDH1A1CYP3A4SETDB1 | |
| SCHEMBL7789892 | 0.78 | POLB (0.42) | GAAPOLBLMNAALDH1A1CYP3A4 | |
| SCHEMBL29712851 | 0.78 | IDO1 (0.50) | GAACYP3A4P2RX7IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023141432-A2 | APOL1 INHIBITORS AND METHODS OF USE | MAZE THERAPEUTICS, INC. (US) | 2023-07-27 | — | — | WO | disclosed |