Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 5/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | GNRHR | P30968 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TOP1 | P11387 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1460691 | 0.83 | ADRB2 (0.50) | KDM4EALDH1A1HPGDHSD17B10GNRHR | |
| SCHEMBL3820416 | 0.79 | TOP1 (0.44) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL7158963 | 0.78 | KDM4E (0.49) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL3869157 | 0.76 | KDM4E (0.42) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL1460695 | 0.74 | GNRHR (0.36) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL1440873 | 0.74 | HPGD (0.42) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL10857506 | 0.74 | HPGD (0.44) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL7511600 | 0.72 | TOP1 (0.42) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL10916564 | 0.71 | KDM4E (0.77) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL6167648 | 0.68 | TDP1 (0.41) | KDM4EALDH1A1HPGDHSD17B10PMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011031740-A1 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS | ACHAOGEN, INC. (US) | 2011-03-17 | — | — | WO | disclosed |