Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 8/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3820416 | 0.90 | TOP1 (0.44) | TOP1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL7158963 | 0.84 | KDM4E (0.49) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL3869157 | 0.81 | KDM4E (0.42) | TOP1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL10857506 | 0.81 | HPGD (0.44) | TOP1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL1440873 | 0.79 | HPGD (0.42) | TOP1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL30944930 | 0.78 | ADRB2 (0.56) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL7011678 | 0.78 | ADRB2 (0.56) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL584797 | 0.77 | STAT3 (0.53) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL9442764 | 0.76 | LMNA (0.58) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL3869129 | 0.76 | TOP1 (0.45) | TOP1KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1226146-A2 | QUINOLINE AND NAPHTHYRIDINE CARBOXYLIC ACID ANTIBACTERIALS | ABBOTT LABORATORIES (US) | 2002-07-31 | — | — | EP | disclosed |
| WO-2001032655-A2 | QUINOLINE AND NAPHTHYRIDINE CARBOXYLIC ACID ANTIBACTERIALS | ABBOTT LABORATORIES (US) | 2001-05-10 | — | — | WO | disclosed |