Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | TOP1 | P11387 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3820416 | 0.89 | TOP1 (0.44) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL7158963 | 0.88 | KDM4E (0.49) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL1440873 | 0.84 | HPGD (0.42) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL10857506 | 0.84 | HPGD (0.44) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL3870889 | 0.82 | FOXO1 (0.40) | KDM4EALDH1A1STAT3HTR3ATDP1 | |
| SCHEMBL7511600 | 0.81 | TOP1 (0.42) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL1344946 | 0.78 | ADRB2 (0.58) | KDM4EALDH1A1HPGDHSD17B10STAT3 | |
| SCHEMBL6167648 | 0.77 | TDP1 (0.41) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL1461785 | 0.76 | KDM4E (0.40) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL584797 | 0.76 | STAT3 (0.53) | KDM4EALDH1A1HPGDHSD17B10PMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013182-A2 | AMINOQUINOLONES AS GSK-3 INHIBITORS | Activx Biosciences, Inc. (US) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007106537-A2 | AMINOQUINOLONES AS GSK-3 INHIBITORS | ACTIVX BIOSCIENCES, INC. (US) | 2007-09-20 | — | — | WO | disclosed |