Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.47 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.47 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.47 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.47 |
| ▸ | FUCA1 | P04066 | 1/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14501542 | 0.93 | MAPK1 (0.55) | ALDH1A1ALOX15MAPK1CYP3A4TSHR | |
| SCHEMBL13807207 | 0.88 | CYP3A4 (0.50) | ALDH1A1ALOX15MAPK1CYP3A4TSHR | |
| SCHEMBL19578530 | 0.88 | HTT (0.53) | ALDH1A1ALOX15LMNASMN1; SMN2TRPM8 | |
| SCHEMBL20299914 | 0.86 | ALDH1A1 (0.62) | ALDH1A1ALOX15CYP3A4TSHRLMNA | |
| SCHEMBL17034708 | 0.86 | ALDH1A1 (0.62) | ALDH1A1ALOX15CYP3A4TSHRLMNA | |
| SCHEMBL21563247 | 0.84 | MAPT (0.57) | ALDH1A1MAPK1CYP3A4TSHRLMNA | |
| SCHEMBL10531968 | 0.83 | MAPK1 (0.56) | ALDH1A1MAPK1CYP3A4TSHRLMNA | |
| SCHEMBL1687312 | 0.82 | ALDH1A1 (0.60) | ALDH1A1MAPK1CYP3A4TSHRLMNA | |
| SCHEMBL9491221 | 0.82 | ATM (0.59) | ALDH1A1ALOX15CYP3A4TSHRCTSL | |
| SCHEMBL330432 | 0.82 | ATM (0.59) | ALDH1A1ALOX15CYP3A4TSHRCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149710-A1 | SORTASE A INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2012-06-14 | — | — | US | disclosed |
| WO-2011028492-A2 | SORTASE A INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-03-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149710-A1 | SORTASE A INHIBITORS | STS, ENGASE, SPR | ALDH1A1 2421/4885ALOX15 2649/4885MAPK1 1214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.