Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | CTSL | P07711 | 1/20 | 0.56 |
| ▸ | CTSB | P07858 | 1/20 | 0.56 |
| ▸ | CTSS | P25774 | 1/20 | 0.56 |
| ▸ | CTSK | P43235 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.54 |
| ▸ | MDM4 | O15151 | 1/20 | 0.54 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9491221 | 1.00 | ATM (0.59) | ATMALDH1A1ALOX15POLBCTSL | |
| SCHEMBL13588071 | 0.95 | MDM4 (0.61) | ATMALDH1A1ALOX15POLBCTSL | |
| SCHEMBL11578841 | 0.95 | CTSL (0.58) | ATMALDH1A1ALOX15POLBCTSL | |
| SCHEMBL11578845 | 0.95 | CTSL (0.58) | ATMALDH1A1ALOX15POLBCTSL | |
| SCHEMBL28902023 | 0.95 | MDM4 (0.61) | ATMALDH1A1ALOX15POLBCTSL | |
| SCHEMBL9440556 | 0.90 | CTSB (0.67) | ALDH1A1ALOX15CTSLCTSBCTSS | |
| SCHEMBL11028843 | 0.90 | TACR1 (0.55) | ALDH1A1ALOX15POLBCTSLCTSB | |
| SCHEMBL22811132 | 0.90 | MAPK1 (0.52) | ALDH1A1ALOX15CTSLCTSBCTSS | |
| SCHEMBL31650945 | 0.90 | ACE (0.56) | ALDH1A1POLBCTSLCTSBCTSS | |
| SCHEMBL8932374 | 0.90 | MAPK1 (0.52) | ALDH1A1ALOX15CTSLCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318798-B2 | Therapeutic agent for neurodegenerative disease | NATIONAL UNIVERSITY CORPORATION HOKKALDO UNIVERSITY (JP) | 2012-11-27 | — | — | US | disclosed |
| EP-2407167-A2 | Therapeutic agent for neurodegenerative disease | National University Corporation Hokkaido University (JP) | 2012-01-18 | — | — | EP | disclosed |
| US-20090233872-A1 | Therapeutic Agent for Neurodegenerative Disease | NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (JP) | 2009-09-17 | — | — | US | disclosed |
| EP-1974732-A1 | THERAPEUTIC AGENT FOR NEURODEGENERATIVE DISEASE | National University Corporation Hokkaido University (JP) | 2008-10-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233872-A1 | Therapeutic Agent for Neurodegenerative Disease | PARK7, HSPD1, FASTKD1 | ATM 2110/4885ALDH1A1 3290/4885ALOX15 567/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.