Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TACR3 | P29371 | 8/20 | 0.44 |
| ▸ | ACACA | Q13085 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL743975 | 0.83 | KDM4E (0.72) | SMN1; SMN2KDM4EALDH1A1TACR3ACACA | |
| SCHEMBL14623967 | 0.80 | KDM4E (0.55) | SMN1; SMN2KDM4EALDH1A1TACR3MEN1 | |
| SCHEMBL12201040 | 0.77 | ESR1 (0.53) | SMN1; SMN2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL1256551 | 0.77 | ACHE (0.61) | SMN1; SMN2KDM4ETACR3ACACALMNA | |
| SCHEMBL20696076 | 0.75 | ACHE (0.59) | SMN1; SMN2KDM4ETACR3ACACALMNA | |
| Methane SCHEMBL10433561 | 0.75 | ACHE (0.59) | SMN1; SMN2KDM4ETACR3ACACALMNA | |
| SCHEMBL10155099 | 0.75 | KDM4E (0.56) | SMN1; SMN2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL6667030 | 0.75 | DHODH (0.54) | SMN1; SMN2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL26999154 | 0.75 | RXFP1 (0.54) | SMN1; SMN2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL16639053 | 0.75 | ACHE (0.47) | SMN1; SMN2KDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007001406-A2 | ARYL-CONTAINING MACROCYCLIC COMPOUNDS | CHIRON CORPORATION (US) | 2007-01-04 | — | — | WO | disclosed |