Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.55 |
| ▸ | RAB9A | P51151 | 6/20 | 0.55 |
| ▸ | LMNA | P02545 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | TACR3 | P29371 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 5/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL743975 | 0.85 | KDM4E (0.72) | KDM4ESMN1; SMN2RAB9ALMNAALDH1A1 | |
| SCHEMBL14623979 | 0.80 | SMN1; SMN2 (0.50) | KDM4ESMN1; SMN2LMNAALDH1A1HPGD | |
| SCHEMBL8381387 | 0.77 | KDM4E (0.78) | KDM4ESMN1; SMN2LMNAALDH1A1HPGD | |
| SCHEMBL10155099 | 0.77 | KDM4E (0.56) | KDM4ESMN1; SMN2RAB9ALMNAALDH1A1 | |
| SCHEMBL12201040 | 0.76 | ESR1 (0.53) | KDM4ESMN1; SMN2LMNAALDH1A1TP53 | |
| SCHEMBL9634226 | 0.76 | LMNA (0.56) | KDM4ESMN1; SMN2RAB9ALMNAALDH1A1 | |
| SCHEMBL1256551 | 0.76 | ACHE (0.61) | KDM4ESMN1; SMN2LMNAHPGDTACR3 | |
| SCHEMBL12732312 | 0.76 | KDM4E (0.58) | KDM4ESMN1; SMN2RAB9ALMNAALDH1A1 | |
| SCHEMBL8614007 | 0.75 | LMNA (0.57) | KDM4ESMN1; SMN2RAB9ALMNAALDH1A1 | |
| SCHEMBL14035489 | 0.75 | DHODH (0.56) | TACR3ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007001406-A2 | ARYL-CONTAINING MACROCYCLIC COMPOUNDS | CHIRON CORPORATION (US) | 2007-01-04 | — | — | WO | disclosed |