Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.48 |
| ▸ | HTR3B | O95264 | 1/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.48 |
| ▸ | HTR3A | P46098 | 1/20 | 0.48 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.48 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16924853 | 0.81 | LMNA (0.67) | MAPTLMNACHRNA7SIGMAR1HTR3E | |
| SCHEMBL576454 | 0.81 | LMNA (0.67) | MAPTLMNACHRNA7SIGMAR1HTR3E | |
| SCHEMBL385012 | 0.81 | — | — | |
| SCHEMBL164538 | 0.81 | LMNA (0.67) | MAPTLMNACHRNA7SIGMAR1HTR3E | |
| SCHEMBL576814 | 0.81 | LMNA (0.67) | MAPTLMNACHRNA7SIGMAR1HTR3E | |
| SCHEMBL10552158 | 0.79 | MAPT (0.52) | MAPTKDM4ELMNADRD4DRD2 | |
| SCHEMBL3076371 | 0.78 | DRD4 (0.52) | MAPTKDM4ELMNACHRNA7SIGMAR1 | |
| SCHEMBL6650835 | 0.78 | LMNA (0.48) | MAPTKDM4ELMNACHRNA7SIGMAR1 | |
| SCHEMBL7258870 | 0.78 | LMNA (0.64) | MAPTLMNACHRNA7SIGMAR1HTR3E | |
| SCHEMBL1280470 | 0.77 | KDM4E (0.56) | USP30MAPTKDM4ELMNAALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3277676-B1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AS DNA METHYLTRANSFERASE INHIBITORS | PF MEDICAMENT (FR) | 2023-03-22 | — | — | EP | disclosed |
| CN-111265525-A | Treatment of hepatitis delta virus infection | 艾格尔峰生物制药有限公司 | 2020-06-12 | — | — | CN | disclosed |
| CN-106535895-B | Treatment of hepatitis delta virus infection | 艾格尔峰生物制药有限公司 | 2020-02-28 | — | — | CN | disclosed |
| US-10450299-B2 | Substituted quinazoline derivatives as DNA methyltransferase inhibitors | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2019-10-22 | — | — | US | disclosed |
| US-10450299-B2 | Substituted quinazoline derivatives as DNA methyltransferase inhibitors | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2019-10-22 | — | — | US | disclosed |
| CN-104211708-B | Benzoxazinone derivatives and its application as antiseptic | 中国医学科学院药物研究所 | 2018-08-24 | — | — | CN | disclosed |
| US-20180118717-A1 | Substituted Quinazoline Derivatives as DNA Methyltransferase Inhibitors | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2018-05-03 | — | — | US | disclosed |
| US-20180118717-A1 | Substituted Quinazoline Derivatives as DNA Methyltransferase Inhibitors | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2018-05-03 | — | — | US | disclosed |
| US-20180118717-A1 | Substituted Quinazoline Derivatives as DNA Methyltransferase Inhibitors | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2018-05-03 | — | — | US | disclosed |
| EP-3277676-A1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AS DNA METHYLTRANSFERASE INHIBITORS | Pierre Fabre Médicament (FR) | 2018-02-07 | — | — | EP | disclosed |
| EP-1622894-B1 | ANTITUMORAL ANTIANDROGENIC PYRROLIDINES | BAYER SCHERING PHARMA AG (DE) | 2009-01-14 | — | — | EP | disclosed |
| WO-2008044033-A1 | AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-04-17 | — | — | WO | disclosed |
| US-20070021481-A1 | Anti-androgenic pyrrolidines with tumor-inhibiting action | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2007-01-25 | — | — | US | disclosed |
| US-7138421-B2 | Anti-androgenic pyrrolidines with tumor-inhibiting action | SCHRING AKTIENGESELLSCHAFT (DE) | 2006-11-21 | — | — | US | disclosed |
| EP-1622894-A1 | ANTITUMORAL ANTIADROGENIC PYRROLIDINES | Schering Aktiengesellschaft (DE) | 2006-02-08 | — | — | EP | disclosed |
| US-20050159468-A1 | Anti-androgenic pyrrolidines with tumor-inhibiting action | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2005-07-21 | — | — | US | disclosed |
| US-6861432-B2 | Piperazine derivatives that destabilize androgen receptors | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-03-01 | — | — | US | disclosed |
| WO-2004099188-A1 | ANTITUMORAL ANTIADROGENIC PYRROLIDINES | SCHERING AKTIENGESELLSCHAFT (DE) | 2004-11-18 | — | — | WO | disclosed |
| US-20040009969-A1 | Piperazine derivatives that destabilize androgen receptors | SCHERING AG (DE) | 2004-01-15 | — | — | US | disclosed |
| WO-2003043983-A1 | PIPERAZINE DERIVATIVES DESTABILISING ANDROGEN RECEPTORS | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021481-A1 | Anti-androgenic pyrrolidines with tumor-inhibiting action | NR5A1, AR, CYP17A1 | USP30 4349/4885MAPT 4842/4885KDM4E 2146/4885 |
| US-10450299-B2 | Substituted quinazoline derivatives as DNA methyltransferase inhibitors | DNMT1, DNMT3A, DNMT3B | USP30 2692/4885MAPT 1559/4885KDM4E 205/4885 |
| US-20050159468-A1 | Anti-androgenic pyrrolidines with tumor-inhibiting action | NR5A1, AR, CYP17A1 | USP30 4349/4885MAPT 4842/4885KDM4E 2146/4885 |
| US-20040009969-A1 | Piperazine derivatives that destabilize androgen receptors | AR, FSHR, GNRHR | USP30 2316/4885MAPT 4808/4885KDM4E 1947/4885 |
| US-20180118717-A1 | Substituted Quinazoline Derivatives as DNA Methyltransferase Inhibitors | DNMT1, DNMT3A, DNMT3B | USP30 2692/4885MAPT 1559/4885KDM4E 205/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.