Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ME2 | P23368 | 4/20 | 0.41 |
| ▸ | ME1 | P48163 | 4/20 | 0.41 |
| ▸ | ME3 | Q16798 | 4/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7041242 | 0.82 | MAPT (0.68) | MAPTKDM4EALDH1A1PKMDRD4 | |
| SCHEMBL7781694 | 0.80 | KDM4E (0.67) | MAPTKDM4EALDH1A1PKMDRD4 | |
| SCHEMBL1462575 | 0.79 | USP30 (0.51) | MAPTKDM4EALDH1A1DRD4LMNA | |
| SCHEMBL1280470 | 0.78 | KDM4E (0.56) | MAPTKDM4EALDH1A1LMNATP53 | |
| SCHEMBL7106841 | 0.76 | KDM4E (0.61) | MAPTKDM4EALDH1A1PKMDRD4 | |
| SCHEMBL6237643 | 0.76 | CA2 (0.51) | KDM4ETP53ME2ME1ME3 | |
| SCHEMBL28923884 | 0.75 | MAPT (0.55) | MAPTKDM4EALDH1A1PKMDRD4 | |
| SCHEMBL8931737 | 0.74 | DRD4 (0.67) | MAPTKDM4EALDH1A1PKMDRD4 | |
| SCHEMBL3043144 | 0.73 | ALDH1A1 (0.57) | MAPTKDM4EALDH1A1PKMDRD4 | |
| SCHEMBL657027 | 0.73 | ALDH1A1 (0.57) | MAPTKDM4EALDH1A1PKMDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4833141-A | FUNGICIDES | HEUMANN PHARMA GMBH & CO. (DE) | 1989-05-23 | — | — | US | disclosed |
| EP-0253166-A2 | 1,4-Piperazine derivatives, process for their preparation, their use and therapeutical agent containing them | HEUMANN PHARMA GMBH & CO (DE) | 1988-01-20 | — | — | EP | disclosed |