SCHEMBL6650835

SCHEMBL6650835

C#CN1CCN(c2ccccc2)CC1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.48
CHRNA7 P36544 2/20 0.48
MAPT P10636 2/20 0.48
SIGMAR1 Q99720 2/20 0.48
HTR3E A5X5Y0 1/20 0.48
HTR3B O95264 1/20 0.48
ADRB1 P08588 1/20 0.48
HTR3A P46098 1/20 0.48
HTR3D Q70Z44 1/20 0.48
HTR3C Q8WXA8 1/20 0.48
DRD4 P21917 2/20 0.47
KCNH2 Q12809 1/20 0.47
DRD2 P14416 3/20 0.46
MAPK1 P28482 2/20 0.45
CYP3A4 P08684 1/20 0.45
ALOX15 P16050 1/20 0.45
CHRNB2 P17787 1/20 0.45
NFKB1 P19838 1/20 0.45
CHRNA3 P32297 1/20 0.45
CHRNA4 P43681 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL164538 0.81 LMNA (0.67) LMNACHRNA7MAPTSIGMAR1HTR3E
SCHEMBL576814 0.81 LMNA (0.67) LMNACHRNA7MAPTSIGMAR1HTR3E
SCHEMBL385012 0.81
SCHEMBL576454 0.81 LMNA (0.67) LMNACHRNA7MAPTSIGMAR1HTR3E
SCHEMBL16924853 0.81 LMNA (0.67) LMNACHRNA7MAPTSIGMAR1HTR3E
SCHEMBL23764850 0.79 MAPT (0.57) LMNAMAPTMAPK1ALOX15HSD17B10
SCHEMBL1462575 0.78 USP30 (0.51) LMNACHRNA7MAPTSIGMAR1HTR3E
SCHEMBL3076371 0.78 DRD4 (0.52) LMNACHRNA7MAPTSIGMAR1HTR3E
SCHEMBL7258870 0.78 LMNA (0.64) LMNACHRNA7MAPTSIGMAR1HTR3E
SCHEMBL10371845 0.77 ALDH1A1 (0.58) LMNAMAPTSIGMAR1HTR3EHTR3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1317459-B1 BICYCLIC PYRROLYL AMIDES AS GLUCOGEN PHOSPHORYLASE INHIBITORS ASTRAZENECA AB (SE) 2004-04-07 EP claimed
EP-0863756-A1 USE OF 2-IMINOBENZOTHIAZOLINES FOR TREATING PARKINSON'S DISEASE AND PARKINSONIAN SYNDROMES Aventis Pharma S.A. (FR) 1998-09-16 EP claimed
WO-1997020558-A1 USE OF 2-IMINOBENZOTHIAZOLINES FOR TREATING PARKINSON'S DISEASE AND PARKINSONIAN SYNDROMES RHONE-POULENC RORER S.A. (FR) 1997-06-12 WO claimed
EP-0863756-A1 USE OF 2-IMINOBENZOTHIAZOLINES FOR TREATING PARKINSON'S DISEASE AND PARKINSONIAN SYNDROMES Aventis Pharma S.A. (FR) 1998-09-16 EP disclosed
EP-0863756-A1 USE OF 2-IMINOBENZOTHIAZOLINES FOR TREATING PARKINSON'S DISEASE AND PARKINSONIAN SYNDROMES Aventis Pharma S.A. (FR) 1998-09-16 EP disclosed
WO-1997020558-A1 USE OF 2-IMINOBENZOTHIAZOLINES FOR TREATING PARKINSON'S DISEASE AND PARKINSONIAN SYNDROMES RHONE-POULENC RORER S.A. (FR) 1997-06-12 WO disclosed
WO-1997020558-A1 USE OF 2-IMINOBENZOTHIAZOLINES FOR TREATING PARKINSON'S DISEASE AND PARKINSONIAN SYNDROMES RHONE-POULENC RORER S.A. (FR) 1997-06-12 WO disclosed