SCHEMBL1462675

SCHEMBL1462675

COC[C@H]1C[C@H](O)CN1C(=O)OC(C)(C)C

nearest known ligand 0.44

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.44
POLB P06746 1/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2C19 P33261 1/20 0.44
CHRM2 P08172 1/20 0.43
CHRM1 P11229 1/20 0.43
CHRM3 P20309 1/20 0.43
NR1H2 P55055 1/20 0.40
HSD11B1 P28845 1/20 0.33
AR P10275 1/20 0.33
RIPK1 Q13546 1/20 0.33
ATM Q13315 1/20 0.33
PDE4B Q07343 1/20 0.32
HSD17B10 Q99714 1/20 0.32
PREP P48147 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1949659 1.00 CYP1A2 (0.44) CYP1A2POLBCYP3A4CYP2C19CHRM2
SCHEMBL28995745 1.00 CYP1A2 (0.44) CYP1A2POLBCYP3A4CYP2C19CHRM2
SCHEMBL1439401 1.00 CYP1A2 (0.44) CYP1A2POLBCYP3A4CYP2C19CHRM2
SCHEMBL1722643 1.00 CYP1A2 (0.44) CYP1A2POLBCYP3A4CYP2C19CHRM2
SCHEMBL10238568 1.00 CYP1A2 (0.44) CYP1A2POLBCYP3A4CYP2C19CHRM2
SCHEMBL8759154 0.89 CYP1A2 (0.41) CYP1A2POLBCYP3A4CYP2C19CHRM2
SCHEMBL12300132 0.88 CYP1A2 (0.42) CYP1A2POLBCYP3A4CYP2C19CHRM2
SCHEMBL8006914 0.88 CYP1A2 (0.42) CYP1A2POLBCYP3A4CYP2C19CHRM2
SCHEMBL1439543 0.88 CYP1A2 (0.40) CYP1A2POLBCYP3A4CYP2C19CHRM2
SCHEMBL1439540 0.88 CYP1A2 (0.40) CYP1A2POLBCYP3A4CYP2C19CHRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3909584-B1 PYRIMIDINE COMPOUND OR SALT THEREOF TAIHO PHARMACEUTICAL CO LTD (JP) 2023-12-13 EP disclosed
US-20230285397-A1 EGFR INHIBITOR TAIHO PHARMACEUTICAL CO., LTD. (JP) 2023-09-14 US disclosed
US-20230255972-A1 PYRIMIDINE COMPOUND-CONTAINING COMBINATION TO BE USED IN TUMOR TREATMENT TAIHO PHARMACEUTICAL CO., LTD. (JP) 2023-08-17 US disclosed
CN-116368136-A EGFR inhibitors 大鹏药品工业株式会社 2023-06-30 CN disclosed
EP-4197538-A1 EGFR INHIBITOR Taiho Pharmaceutical Co., Ltd. (JP) 2023-06-21 EP disclosed
EP-4183395-A1 PYRIMIDINE COMPOUND-CONTAINING COMBINATION TO BE USED IN TUMOR TREATMENT Taiho Pharmaceutical Co., Ltd. (JP) 2023-05-24 EP disclosed
WO-2012101063-A1 N-ACYL PYRIDINE BIARYL COMPOUNDS AND THEIR USES NOVARTIS AG (CH) 2012-08-02 WO disclosed
WO-2012101064-A1 N-ACYL PYRIMIDINE BIARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS NOVARTIS AG (CH) 2012-08-02 WO disclosed
EP-2473499-A1 BIPYRIDINES USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES Novartis AG (CH) 2012-07-11 EP disclosed
US-20120165306-A1 PYRAZINYLPYRIDINES USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES NOVARTIS VACCINES AND DIAGNOSTICS, INC. 2012-06-28 US disclosed
US-20120157433-A1 Heteroaryl Compounds as Kinase Inhibitors PFISTER KEITH B (US) 2012-06-21 US disclosed
US-20110130380-A1 Heteroaryl Kinase Inhibitors NOVARTIS AG (CH) 2011-06-02 US disclosed
WO-2011026911-A1 BIPYRIDINES USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES NOVARTIS AG (CH) 2011-03-10 WO disclosed
US-20090264431-A1 NOVEL CATHEPSIN C INHIBITORS AND THEIR USE GLAXO GROUP LIMITED (GB) 2009-10-22 US disclosed
WO-2009026197-A1 NOVEL CATHEPSIN C INHIBITORS AND THEIR USE GLAXO GROUP LIMITED (GB) 2009-02-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090264431-A1 NOVEL CATHEPSIN C INHIBITORS AND THEIR USE CTSB, CTSS, CTSF CYP1A2 974/4885POLB 690/4885CYP3A4 2004/4885
US-20230285397-A1 EGFR INHIBITOR EGFR, ERBB2, ERBB4 CYP1A2 3686/4885POLB 4722/4885CYP3A4 4191/4885
US-20230255972-A1 PYRIMIDINE COMPOUND-CONTAINING COMBINATION TO BE USED IN TUMOR TREATMENT TYMP, DPYD, TYMS CYP1A2 3654/4885POLB 481/4885CYP3A4 2607/4885
US-20120157433-A1 Heteroaryl Compounds as Kinase Inhibitors CDK2, CDK1, CDK6 CYP1A2 873/4885POLB 1063/4885CYP3A4 1058/4885
US-20110130380-A1 Heteroaryl Kinase Inhibitors CDK2, CDK1, CDKL1 CYP1A2 617/4885POLB 885/4885CYP3A4 817/4885
US-20120165306-A1 PYRAZINYLPYRIDINES USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES CDK4, CDK1, CCNI CYP1A2 2152/4885POLB 244/4885CYP3A4 2968/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.