Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 19/20 | 0.83 |
| ▸ | THRB | P10828 | 19/20 | 0.83 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14628112 | 0.92 | THRA (0.84) | THRATHRBCYP2C9UGT1A1ABCG2 | |
| SCHEMBL2927006 | 0.91 | THRB (1.00) | THRATHRB | |
| SCHEMBL2925513 | 0.83 | THRB (1.00) | THRATHRBCYP2C9UGT1A1ABCG2 | |
| SCHEMBL2928910 | 0.78 | THRB (1.00) | THRATHRB | |
| SCHEMBL2928389 | 0.78 | THRB (1.00) | THRATHRB | |
| SCHEMBL31054366 | 0.74 | THRA (0.59) | THRATHRBCYP2C9UGT1A1ABCG2 | |
| SCHEMBL22632565 | 0.72 | THRB (0.66) | THRATHRBCYP2C9UGT1A1ABCG2 | |
| SCHEMBL2919636 | 0.72 | THRA (1.00) | THRATHRB | |
| SCHEMBL13116433 | 0.72 | THRA (0.78) | THRATHRBCYP2C9UGT1A1ABCG2 | |
| SCHEMBL2927379 | 0.72 | THRA (0.70) | THRATHRBCYP2C9UGT1A1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007009913-A1 | PYRIDAZINONE DERIVATIVES AS THYROID HORMONE RECEPTOR AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-01-25 | — | — | WO | disclosed |