Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 10/20 | 0.44 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.41 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 2/20 | 0.32 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14628656 | 0.82 | MAPKAPK2 (0.45) | SIRT1SIRT2PARP1KDM4EALDH1A1 | |
| SCHEMBL14628642 | 0.80 | GAA (0.40) | SIRT1IMPDH2IMPDH1GAANPSR1 | |
| SCHEMBL14628606 | 0.78 | PLA2G2A (0.38) | SIRT1KDM4EMEN1ALDH1A1POLB | |
| SCHEMBL14628657 | 0.75 | DDB1 (0.39) | SIRT1KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL7741198 | 0.71 | SIRT1 (0.43) | SIRT1SIRT2GAAPARP1RECQL | |
| SCHEMBL3258128 | 0.70 | SIRT1 (0.63) | SIRT1SIRT2RECQLNR2E1KDM4E | |
| SCHEMBL14598623 | 0.69 | MAPKAPK2 (0.45) | GAAPARP1KDM4EALDH1A1MAPT | |
| Sulfuric Acid SCHEMBL8592514 | 0.67 | SIRT1 (0.57) | SIRT1SIRT2RECQLNR2E1KDM4E | |
| SCHEMBL13960992 | 0.63 | SIRT1 (0.59) | SIRT1SIRT2RECQLSIRT3 | |
| SCHEMBL13960223 | 0.63 | SIRT1 (0.59) | SIRT1SIRT2RECQLSIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7160909-B2 | Cyclopenta[b]indole derivatives as sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 2007-01-09 | — | — | US | disclosed |