Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SI | P14410 | 1/20 | 0.34 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 2/20 | 0.32 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9729760 | 0.88 | MTNR1A (0.35) | SIRT1MTNR1AMTNR1BMGAMGAA | |
| SCHEMBL9643588 | 0.81 | MTNR1A (0.33) | MTNR1AMTNR1BMGAMGAASI | |
| SCHEMBL10430206 | 0.78 | GAA (0.40) | MTNR1AMTNR1BMGAMGAASI | |
| SCHEMBL9642972 | 0.76 | MTNR1A (0.34) | MTNR1AMTNR1BMGAMGAASI | |
| SCHEMBL9729975 | 0.76 | SIRT1 (0.43) | SIRT1SIRT2RECQLMTNR1AMTNR1B | |
| SCHEMBL9642903 | 0.75 | GAA (0.39) | MTNR1AMTNR1BMGAMGAASI | |
| SCHEMBL14628655 | 0.71 | SIRT1 (0.44) | SIRT1SIRT2RECQLGAAPARP1 | |
| SCHEMBL15129413 | 0.70 | P2RX7 (0.42) | SIRT1GAAPARP1 | |
| SCHEMBL16395306 | 0.70 | P2RX7 (0.42) | SIRT1GAAPARP1 | |
| SCHEMBL16395440 | 0.70 | P2RX7 (0.42) | SIRT1GAAPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6423870-B1 | ANTICOAGULANTS; CIRCADIAN RHYTHM DISORDERS; SLEEP DISORDERS | LES LABORATOIRES SERVIER (FR) | 2002-07-23 | — | — | US | claimed |
| JP-2078660-A | — | — | None | — | — | JP | disclosed |
| US-6423870-B1 | ANTICOAGULANTS; CIRCADIAN RHYTHM DISORDERS; SLEEP DISORDERS | LES LABORATOIRES SERVIER (FR) | 2002-07-23 | — | — | US | disclosed |
| US-5079258-A | Enzyme inhibitors, antiallergens treatment of asthma | BAYER AKTIENGESELLSCHAFT (DE) | 1992-01-07 | — | — | US | disclosed |
| JP-H0278660-A | TETRAHYDRO-1-BENZ-(C,D)-INDOLEPROPIONIC ACID SULFONAMIDES | BAYER AG | 1990-03-19 | — | — | JP | disclosed |