Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.37 |
| ▸ | HPGD | P15428 | 5/20 | 0.37 |
| ▸ | CASP1 | P29466 | 2/20 | 0.37 |
| ▸ | CASP7 | P55210 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL231430 | 0.88 | HSD17B10 (0.51) | MAPTTP53HSD17B10TSHRPOLB | |
| SCHEMBL15456785 | 0.83 | MAPT (0.42) | MAPTTP53HSD17B10POLBGAA | |
| SCHEMBL14632007 | 0.78 | ELANE (0.55) | ELANE | |
| SCHEMBL1744039 | 0.77 | MAPT (0.48) | MAPTTP53TSHRPOLBGAA | |
| SCHEMBL2742310 | 0.71 | TSHR (0.67) | MAPTTP53HSD17B10TSHRPOLB | |
| SCHEMBL2742309 | 0.71 | TSHR (0.57) | MAPTTP53HSD17B10TSHRPOLB | |
| SCHEMBL15462620 | 0.69 | ELANE (0.54) | ELANE | |
| SCHEMBL231034 | 0.69 | ALDH1A1 (0.55) | MAPTTP53HSD17B10TSHRPOLB | |
| SCHEMBL12329664 | 0.69 | ALDH1A1 (0.55) | MAPTTP53HSD17B10TSHRPOLB | |
| SCHEMBL2742308 | 0.69 | ALDH1A1 (0.59) | MAPTTP53HSD17B10TSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2385945-B1 | TRIAZOLO AND TETRAZOLO PYRIMIDINE DERIVATIVES AS HNE INHIBITORS FOR TREATING COPD | BAYER IP GMBH (DE) | 2013-01-23 | — | — | EP | disclosed |