Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | TSHR | P16473 | 4/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2742309 | 0.94 | TSHR (0.57) | ALDH1A1TSHRPOLBHSD17B10KDM4E | |
| SCHEMBL2742310 | 0.90 | TSHR (0.67) | ALDH1A1TSHRPOLBHSD17B10KDM4E | |
| SCHEMBL231970 | 0.88 | CYP1A2 (0.43) | ALDH1A1TSHRPOLBHSD17B10KDM4E | |
| SCHEMBL231034 | 0.88 | ALDH1A1 (0.55) | ALDH1A1TSHRPOLBHSD17B10KDM4E | |
| SCHEMBL2742308 | 0.87 | ALDH1A1 (0.59) | ALDH1A1TSHRPOLBHSD17B10KDM4E | |
| SCHEMBL14937791 | 0.83 | ALDH1A1 (0.51) | ALDH1A1TSHRPOLBHSD17B10KDM4E | |
| SCHEMBL231430 | 0.82 | HSD17B10 (0.51) | ALDH1A1TSHRPOLBHSD17B10KDM4E | |
| SCHEMBL14937838 | 0.82 | ALDH1A1 (0.50) | ALDH1A1TSHRPOLBHSD17B10KDM4E | |
| SCHEMBL231063 | 0.82 | ALDH1A1 (0.49) | ALDH1A1TSHRPOLBHSD17B10KDM4E | |
| SCHEMBL230555 | 0.82 | LMNA (0.64) | ALDH1A1TSHRPOLBMAPK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2545057-B1 | PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF RESPIRATORY DISEASES SUCH AS COPD | CHIESI FARM SPA (IT) | 2017-06-07 | — | — | EP | disclosed |
| EP-2545057-B1 | PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF RESPIRATORY DISEASES SUCH AS COPD | CHIESI FARM SPA (IT) | 2017-06-07 | — | — | EP | disclosed |
| US-9120802-B2 | Pyrimidine derivatives and their use in the treatment of respiratory diseases such as COPD | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-09-01 | — | — | US | disclosed |
| US-9120802-B2 | Pyrimidine derivatives and their use in the treatment of respiratory diseases such as COPD | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-09-01 | — | — | US | disclosed |
| US-9120802-B2 | Pyrimidine derivatives and their use in the treatment of respiratory diseases such as COPD | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-09-01 | — | — | US | disclosed |
| US-20130123278-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF RESPIRATORY DISEASES SUCH AS COPD | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-05-16 | — | — | US | disclosed |
| US-20130123278-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF RESPIRATORY DISEASES SUCH AS COPD | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-05-16 | — | — | US | disclosed |
| US-20130123278-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF RESPIRATORY DISEASES SUCH AS COPD | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-05-16 | — | — | US | disclosed |
| WO-2011110859-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF RESPIRATORY DISEASES SUCH AS COPD | PULMAGEN THERAPEUTICS (INFLAMMATION) LIMITED (GB) | 2011-09-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130123278-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF RESPIRATORY DISEASES SUCH AS COPD | XDH, SERPINB1, CCR9 | ALDH1A1 1182/4885TSHR 1591/4885POLB 188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.