Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.70 |
| ▸ | RAB9A | P51151 | 2/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.65 |
| ▸ | MAPT | P10636 | 4/20 | 0.65 |
| ▸ | HPGD | P15428 | 3/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14633997 | 0.85 | KDM4E (0.65) | NPC1KDM4ERAB9ANPSR1SMN1; SMN2 | |
| SCHEMBL7432215 | 0.84 | KDM4E (0.97) | NPC1KDM4ERAB9ANPSR1SMN1; SMN2 | |
| SCHEMBL195575 | 0.82 | KDM4E (1.00) | NPC1KDM4ERAB9ANPSR1SMN1; SMN2 | |
| SCHEMBL31038267 | 0.82 | KDM4E (1.00) | NPC1KDM4ERAB9ANPSR1SMN1; SMN2 | |
| SCHEMBL19291257 | 0.82 | KDM4E (0.53) | NPC1KDM4ERAB9ANPSR1SMN1; SMN2 | |
| SCHEMBL14633480 | 0.81 | MAPT (0.69) | NPC1KDM4ESMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL14633519 | 0.81 | KDM4E (0.51) | NPC1KDM4ERAB9ANPSR1SMN1; SMN2 | |
| SCHEMBL7435442 | 0.80 | KDM4E (0.75) | NPC1KDM4ERAB9ANPSR1SMN1; SMN2 | |
| SCHEMBL15111342 | 0.79 | ALDH1A1 (0.49) | NPC1KDM4ERAB9ANPSR1SMN1; SMN2 | |
| SCHEMBL14633914 | 0.79 | DRD2 (0.55) | NPC1KDM4ERAB9ANPSR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9938262-B2 | Benzamides | MERCK PATENT GMBH (DE) | 2018-04-10 | — | — | US | disclosed |
| US-9938262-B2 | Benzamides | MERCK PATENT GMBH (DE) | 2018-04-10 | — | — | US | disclosed |
| US-9938262-B2 | Benzamides | MERCK PATENT GMBH (DE) | 2018-04-10 | — | — | US | disclosed |
| EP-3263568-A1 | BENZAMIDES | Merck Patent GmbH (DE) | 2018-01-03 | — | — | EP | disclosed |
| EP-2734517-B1 | BENZAMIDES | MERCK PATENT GMBH (DE) | 2017-08-30 | — | — | EP | disclosed |
| EP-2734517-B1 | BENZAMIDES | MERCK PATENT GMBH (DE) | 2017-08-30 | — | — | EP | disclosed |
| US-20170022191-A1 | BENZAMIDES | MERCK PATENT GMBH (DE) | 2017-01-26 | — | — | US | disclosed |
| US-20170022191-A1 | BENZAMIDES | MERCK PATENT GMBH (DE) | 2017-01-26 | — | — | US | disclosed |
| US-20170022191-A1 | BENZAMIDES | MERCK PATENT GMBH (DE) | 2017-01-26 | — | — | US | disclosed |
| US-9498475-B2 | Benzamides | MERCK PATENT GMBH (DE) | 2016-11-22 | — | — | US | disclosed |
| US-20160022670-A1 | BENZAMIDES | MERCK PATENT GMBH (DE) | 2016-01-28 | — | — | US | disclosed |
| US-20160022670-A1 | BENZAMIDES | MERCK PATENT GMBH (DE) | 2016-01-28 | — | — | US | disclosed |
| US-9181226-B2 | Benzamides | MERCK PATENT GMBH (DE) | 2015-11-10 | — | — | US | disclosed |
| US-9181226-B2 | Benzamides | MERCK PATENT GMBH (DE) | 2015-11-10 | — | — | US | disclosed |
| US-9181226-B2 | Benzamides | MERCK PATENT GMBH (DE) | 2015-11-10 | — | — | US | disclosed |
| EP-2734517-A1 | BENZAMIDES | Merck Patent GmbH (DE) | 2014-05-28 | — | — | EP | disclosed |
| WO-2013012848-A1 | BENZAMIDES | MERCK PATENT GMBH (DE) | 2013-01-24 | — | — | WO | disclosed |
| US-20130023522-A1 | BENZAMIDES | MERCK PATENT GMBH (DE) | 2013-01-24 | — | — | US | disclosed |
| US-20130023522-A1 | BENZAMIDES | MERCK PATENT GMBH (DE) | 2013-01-24 | — | — | US | disclosed |
| US-20130023522-A1 | BENZAMIDES | MERCK PATENT GMBH (DE) | 2013-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160022670-A1 | BENZAMIDES | FSHR, GNRHR, LHCGR | NPC1 3935/4885KDM4E 757/4885RAB9A 2364/4885 |
| US-20170022191-A1 | BENZAMIDES | FSHR, GNRHR, LHCGR | NPC1 3935/4885KDM4E 757/4885RAB9A 2364/4885 |
| US-20130023522-A1 | BENZAMIDES | FSHR, GNRHR, LHCGR | NPC1 3787/4885KDM4E 645/4885RAB9A 1887/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.