Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cocarboxylase. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | TKT | P29401 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | RNASEL | Q05823 | 6/20 | 0.53 |
| ▸ | P2RY2 | P41231 | 3/20 | 0.51 |
| ▸ | P2RY1 | P47900 | 3/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.50 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.50 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.50 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MACROD2 | A1Z1Q3 | 1/20 | 0.49 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.49 |
| ▸ | MACROD1 | Q9BQ69 | 1/20 | 0.49 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adenosine SCHEMBL675657 | 0.99 | LMNA (0.62) | LMNATKTTDP1RNASELP2RY2 | |
| Adenosine SCHEMBL2702312 | 0.94 | LMNA (0.56) | LMNATKTTDP1RNASELP2RY2 | |
| Hydrochloric Acid SCHEMBL7793647 | 0.92 | TDP1 (0.55) | LMNATKTTDP1RNASEL | |
| SCHEMBL675658 | 0.91 | LMNA (0.58) | LMNATKTTDP1RNASELP2RY2 | |
| Adenosine SCHEMBL6862749 | 0.90 | HSP90AA1 (0.53) | LMNATKTTDP1RNASELP2RY2 | |
| SCHEMBL31005215 | 0.90 | P2RY1 (0.56) | LMNARNASELP2RY2P2RY1SRC | |
| SCHEMBL14636151 | 0.90 | TKT (0.56) | LMNATKTTDP1RNASELP2RY2 | |
| Adenosine SCHEMBL15347371 | 0.88 | HSP90AA1 (0.57) | SMN1; SMN2 | |
| SCHEMBL6862756 | 0.86 | TDP1 (0.53) | LMNATKTTDP1RNASELP2RY2 | |
| Adenosine Triphosphate SCHEMBL28087656 | 0.84 | P2RY1 (0.56) | RNASELP2RY2P2RY1SRCP2RX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4387444-A1 | CELL TRANSPORT AND STORAGE COMPOSITION AND METHOD | Life Science Group Limited (GB) | 2024-06-26 | — | — | EP | disclosed |
| CN-114364267-B | Novel flavor composition, preparation method and application thereof | 国际香料和香精公司 | 2024-01-30 | — | — | CN | disclosed |
| WO-2023021279-A1 | CELL TRANSPORT AND STORAGE COMPOSITION AND METHOD | Life Science Group Limited (GB) | 2023-02-23 | — | — | WO | disclosed |
| EP-3996524-A1 | NOVEL FLAVOR COMPOSITION AND METHODS OF PREPARATION AND USES THEREOF | International Flavors and Fragrances Inc. (US) | 2022-05-18 | — | — | EP | disclosed |
| CN-114364267-A | Novel flavor composition, preparation method and application thereof | 国际香料和香精公司 | 2022-04-15 | — | — | CN | disclosed |
| WO-2021007476-A1 | NOVEL FLAVOR COMPOSITION AND METHODS OF PREPARATION AND USES THEREOF | INTERNATIONAL FLAVORS AND FRAGRANCES INC. (US) | 2021-01-14 | — | — | WO | disclosed |
| US-10179155-B2 | Phosphodiesterase-4 inhibiting phytochemical compositions | NATURE'S SUNSHINE PRODUCTS, INC. (US) | 2019-01-15 | — | — | US | disclosed |
| WO-2018218287-A1 | TREATMENT AND/OR PREVENTION OF NEUROPATHIC SYMPTOMS ASSOCIATED WITH DIABETES MELLITUS TYPE II | Woodlinda Pty Ltd (AU) | 2018-12-06 | — | — | WO | disclosed |
| US-20170065653-A1 | Phosphodiesterase Inhibiting Phytochemical Compositions | NATURE'S SUNSHINE PRODUCTS, INC. (US) | 2017-03-09 | — | — | US | disclosed |
| US-20170065652-A1 | Phosphodiesterase-4 Inhibiting Phytochemical Compositions | NATURE'S SUNSHINE PRODUCTS, INC. (US) | 2017-03-09 | — | — | US | disclosed |
| WO-2015130995-A1 | PHOSPHODIESTERASE INHIBITING PHYTOCHEMICAL COMPOSITIONS | TRIPP MATTHEW L (US) | 2015-09-03 | — | — | WO | disclosed |
| WO-2015130994-A1 | PHOSPHODIESTERASE-4 INHIBITING PHYTOCHEMICAL COMPOSITIONS | TRIPP MATTHEW L (US) | 2015-09-03 | — | — | WO | disclosed |
| EP-2734847-A1 | METHOD AND ANALYTICAL KIT FOR SIMULTANEOUS QUANTIFICATION OF B-COMPLEX VITAMIN CONTENT IN FOOD | Tallinn University Of Technology (EE) | 2014-05-28 | — | — | EP | disclosed |
| US-20130102624-A1 | EARLY DETECTION OF THIAMINE DEFICIENCY | SCHLOSS JOHN V (US) | 2013-04-25 | — | — | US | disclosed |
| WO-2013010553-A1 | METHOD AND ANALYTICAL KIT FOR SIMULTANEOUS QUANTIFICATION OF B-COMPLEX VITAMIN CONTENT IN FOOD | TALLINN UNIVERSITY OF TECHNOLOGY (EE) | 2013-01-24 | — | — | WO | disclosed |