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Hydrochloric Acid

Hydrochloric Acid

SCHEMBL7793647

Cc1ncc(C[n+]2csc(CCOP(=O)(O)O[C@H]3[C@@H](O)[C@H](n4cnc5c(N)ncnc54)O[C@@H]3CO)c2C)c(N)n1.[Cl-]

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 1/20 0.55
▸ RNASEL Q05823 10/20 0.55
▸ LMNA P02545 1/20 0.55
▸ TKT P29401 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cocarboxylase SCHEMBL14636148 0.92 LMNA (0.63) TDP1RNASELLMNATKT
Adenosine SCHEMBL675657 0.91 LMNA (0.62) TDP1RNASELLMNATKT
Adenosine SCHEMBL2702312 0.89 LMNA (0.56) TDP1RNASELLMNATKT
Adenosine SCHEMBL6862749 0.87 HSP90AA1 (0.53) TDP1RNASELLMNATKT
SCHEMBL31005215 0.86 P2RY1 (0.56) RNASELLMNA
SCHEMBL6862756 0.85 TDP1 (0.53) TDP1RNASELLMNATKT
Adenosine SCHEMBL15347371 0.85 HSP90AA1 (0.57) —
SCHEMBL675658 0.85 LMNA (0.58) TDP1RNASELLMNATKT
SCHEMBL14636151 0.85 TKT (0.56) TDP1RNASELLMNATKT
Hydrochloric Acid SCHEMBL5946679 0.78 LMNA (0.79) TDP1LMNATKT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1155143-A1 DETERMINATION OF NUCLEASE ACTIVITY Zetatronics Limited (GB) 2001-11-21 — — EP disclosed
WO-2000049172-A1 DETERMINATION OF NUCLEASE ACTIVITY ZETATRONICS LIMITED (GB) 2000-08-24 — — WO disclosed