SCHEMBL14636173

SCHEMBL14636173

CC(=O)c1ccc(Oc2ccc(F)cc2F)cc1Cl

nearest known ligand 0.47

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.47
HTR2A P28223 5/20 0.46
SLC6A4 P31645 5/20 0.46
KCNH2 Q12809 5/20 0.46
HSPB1 P04792 1/20 0.46
PNLIP P16233 3/20 0.46
SCN9A Q15858 1/20 0.44
MAOB P27338 2/20 0.43
SCN8A Q9UQD0 1/20 0.42
SCN10A Q9Y5Y9 1/20 0.42
MAPK14 Q16539 1/20 0.42
SCN4A P35499 1/20 0.42
PARG Q86W56 1/20 0.42
MAOA P21397 1/20 0.41
AR P10275 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14649487 0.88 SCN8A (0.45) LMNAHTR2ASLC6A4KCNH2PNLIP
SCHEMBL28385096 0.84 LMNA (0.47) LMNAHTR2ASLC6A4KCNH2HSPB1
SCHEMBL5310179 0.82 HTR2A (0.54) HTR2ASLC6A4KCNH2PNLIPSCN9A
SCHEMBL753397 0.80 XIAP (0.47) PNLIPPARG
SCHEMBL22406889 0.80 MAOB (0.48) HTR2ASLC6A4KCNH2SCN9AMAOB
SCHEMBL22406973 0.80 MAOB (0.51) SCN9AMAOBMAOA
SCHEMBL22406783 0.79 MAOB (0.45) SCN9AMAOBMAOA
SCHEMBL22407108 0.78 MRGPRX4 (0.54) LMNAPNLIP
SCHEMBL30231714 0.78 HPGD (0.53) LMNA
SCHEMBL473969 0.78 HPGD (0.53) LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3712135-B1 AZOLE DERIVATIVE, INTERMEDIATE COMPOUND, METHOD FOR PRODUCING AZOLE DERIVATIVE, AGENT FOR AGRICULTURAL AND HORTICULTURAL USE, AND MATERIAL PROTECTION AGENT FOR INDUSTRIAL USE KUREHA CORP (JP) 2023-05-03 EP disclosed
CN-111032631-B Azole derivative, intermediate compound, process for producing azole derivative, agricultural and horticultural chemical, and industrial material protective agent 株式会社吴羽 2021-05-07 CN disclosed
US-10945434-B2 Azole derivative, intermediate compound, method for producing azole derivative, agricultural or horticultural chemical agent, and protective agent for industrial material KUREHA CORPORATION (JP) 2021-03-16 US disclosed
EP-3712135-A1 AZOLE DERIVATIVE, INTERMEDIATE COMPOUND, METHOD FOR PRODUCING AZOLE DERIVATIVE, AGENT FOR AGRICULTURAL AND HORTICULTURAL USE, AND MATERIAL PROTECTION AGENT FOR INDUSTRIAL USE Kureha Corporation (JP) 2020-09-23 EP disclosed
US-20200288714-A1 AZOLE DERIVATIVE, INTERMEDIATE COMPOUND, METHOD FOR PRODUCING AZOLE DERIVATIVE, AGRICULTURAL OR HORTICULTURAL CHEMICAL AGENT, AND PROTECTIVE AGENT FOR INDUSTRIAL MATERIAL KUREHA CORPORATION (JP) 2020-09-17 US disclosed
CN-111032631-A Azole derivative, intermediate compound, process for producing azole derivative, agricultural and horticultural chemical, and industrial material protective agent 株式会社吴羽 2020-04-17 CN disclosed
US-9137996-B2 Fungicidal alkyl- and aryl-substituted 2[-2-chloro-4-(dihalo-phenoxy)-phenyl]-1-[1,2,4]triazol-1-yl-ethanol compounds BASF SE (DE) 2015-09-22 US disclosed
US-9137996-B2 Fungicidal alkyl- and aryl-substituted 2[-2-chloro-4-(dihalo-phenoxy)-phenyl]-1-[1,2,4]triazol-1-yl-ethanol compounds BASF SE (DE) 2015-09-22 US disclosed
US-9137996-B2 Fungicidal alkyl- and aryl-substituted 2[-2-chloro-4-(dihalo-phenoxy)-phenyl]-1-[1,2,4]triazol-1-yl-ethanol compounds BASF SE (DE) 2015-09-22 US disclosed
US-20140141973-A1 FUNGICIDAL ALKYL- AND ARYL-SUBSTITUTED 2-[2-CHLORO-4-(DIHALO-PHENOXY)-PHENYL]-1-[1,2,4]TRIAZOL-1-YL-ETHANOL COMPOUNDS BASF SE (DE) 2014-05-22 US disclosed
US-20140141973-A1 FUNGICIDAL ALKYL- AND ARYL-SUBSTITUTED 2-[2-CHLORO-4-(DIHALO-PHENOXY)-PHENYL]-1-[1,2,4]TRIAZOL-1-YL-ETHANOL COMPOUNDS BASF SE (DE) 2014-05-22 US disclosed
US-20140141973-A1 FUNGICIDAL ALKYL- AND ARYL-SUBSTITUTED 2-[2-CHLORO-4-(DIHALO-PHENOXY)-PHENYL]-1-[1,2,4]TRIAZOL-1-YL-ETHANOL COMPOUNDS BASF SE (DE) 2014-05-22 US disclosed
EP-2731934-A1 FUNGICIDAL ALKYL- AND ARYL-SUBSTITUTED 2-[2-CHLORO-4-(DIHALO-PHENOXY)-PHENYL]-1-[1,2,4]TRIAZOL-1-YL-ETHANOL COMPOUNDS BASF SE (DE) 2014-05-21 EP disclosed
WO-2013010885-A1 FUNGICIDAL ALKYL- AND ARYL-SUBSTITUTED 2-[2-CHLORO-4-(DIHALO-PHENOXY)-PHENYL]-1-[1,2,4]TRIAZOL-1-YL-ETHANOL COMPOUNDS BASF SE (DE) 2013-01-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140141973-A1 FUNGICIDAL ALKYL- AND ARYL-SUBSTITUTED 2-[2-CHLORO-4-(DIHALO-PHENOXY)-PHENYL]-1-[1,2,4]TRIAZOL-1-YL-ETHANOL COMPOUNDS TH, CYP1A1, CYP2E1 LMNA 4382/4885HTR2A 1566/4885SLC6A4 1681/4885
US-10945434-B2 Azole derivative, intermediate compound, method for producing azole derivative, agricultural or horticultural chemical agent, and protective agent for industrial material NOS2, NOS1, CYP51A1 LMNA 1892/4885HTR2A 4642/4885SLC6A4 3165/4885
US-20200288714-A1 AZOLE DERIVATIVE, INTERMEDIATE COMPOUND, METHOD FOR PRODUCING AZOLE DERIVATIVE, AGRICULTURAL OR HORTICULTURAL CHEMICAL AGENT, AND PROTECTIVE AGENT FOR INDUSTRIAL MATERIAL NOS2, NOS1, CYP51A1 LMNA 1892/4885HTR2A 4642/4885SLC6A4 3165/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.