SCHEMBL146376

SCHEMBL146376

C[C@](N)(C(=O)O)c1cccc2ccccc12

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.50
ALDH1A1 P00352 1/20 0.50
HSD17B10 Q99714 1/20 0.50
ACP3 P15309 1/20 0.46
NR4A1 P22736 1/20 0.44
NR4A2 P43354 1/20 0.44
NR4A3 Q92570 1/20 0.44
KIF11 P52732 1/20 0.43
PPARG P37231 3/20 0.43
PPARA Q07869 3/20 0.43
CYP2C19 P33261 3/20 0.43
CYP2C9 P11712 1/20 0.43
PPARD Q03181 1/20 0.43
GAA P10253 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
CYP1A2 P05177 1/20 0.41
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
CDC25B P30305 1/20 0.40
PLK1 P53350 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL288855 1.00 KDM4E (0.50) KDM4EALDH1A1HSD17B10ACP3NR4A1
SCHEMBL198219 1.00 KDM4E (0.50) KDM4EALDH1A1HSD17B10ACP3NR4A1
SCHEMBL29608063 1.00 KDM4E (0.50) KDM4EALDH1A1HSD17B10ACP3NR4A1
SCHEMBL4963997 0.90 ALDH1A1 (0.45) KDM4EALDH1A1HSD17B10ACP3NR4A1
SCHEMBL7287554 0.85 KDM4E (0.53) KDM4EALDH1A1HSD17B10ACP3NR4A1
SCHEMBL27165013 0.85 KDM4E (0.39) KDM4EALDH1A1HSD17B10ACP3KIF11
SCHEMBL28252994 0.83 KIF11 (0.49) KDM4EALDH1A1KIF11TDP1MEN1
Norleucine SCHEMBL28063292 0.82 KIF11 (0.51) KDM4EALDH1A1HSD17B10KIF11TDP1
SCHEMBL27575255 0.82 KIF11 (0.40) KDM4EALDH1A1HSD17B10ACP3KIF11
SCHEMBL4678773 0.81 KDM4E (0.53) KDM4EALDH1A1HSD17B10ACP3NR4A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 6994 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4719486-A1 CONJUGATES AND USES THEREOF Full-Life Technologies UK Limited (GB) 2026-04-08 EP claimed
EP-4717776-A2 POLYPEPTIDE CONJUGATES FOR INTRACELLULAR DELIVERY OF NUCLEIC ACIDS Ohio State Innovation Foundation (US) 2026-04-01 EP claimed
US-12589171-B2 177-Lu labeled peptide for site-specific uPAR-targeting TRT INNOVATIONS APS (DK) 2026-03-31 US claimed
EP-4709739-A1 ANTI-BACTERIAL PEPTIDES Agency for Science, Technology and Research (SG) 2026-03-18 EP claimed
EP-4448020-B1 UROKINASE-TYPE PLASMINOGEN ACTIVATOR RECEPTOR (UPAR)-PET/CT IN NEUROENDOCRINE NEOPLAMS CURASIGHT AS (DK) 2026-02-04 EP claimed
US-12540161-B2 Linkers BICYCLETX LIMITED (GB) 2026-02-03 US claimed
EP-4678194-A1 THERAPEUTIC APPLICATION OF 64CU-LABELLED CONJUGATES FOR SITE-SPECIFIC UPAR-TARGETING Curasight A/S (DK) 2026-01-14 EP claimed
US-20250340595-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR TRANSFERRIN RECEPTOR 1 (TfR1) BICYCLETX LTD (GB) 2025-11-06 US claimed
US-20250325672-A1 ANTI-INFECTIVE BICYCLIC PEPTIDE LIGANDS BICYCLE TX LTD (GB) 2025-10-23 US claimed
US-20250319215-A1 UROKINASE-TYPE PLASMINOGEN ACTIVATOR RECEPTOR (UPAR)-PET/CT IN HEAD AND NECK SQUAMOUS CELL CARCINOMAS (HNSCCS) CURASIGHT AS (DK) 2025-10-16 US claimed
US-5204357-A RENIN-INHIBITING AMINO ACID DERIVATIVES HOECHST AKTIENGESELLSCHAFT (DE) 1993-04-20 US claimed
US-5116835-A Hypotensive agents HOECHST AKTIENGESELLSCHAFT (DE) 1992-05-26 US claimed
WO-1992007845-A1 DERIVATIVES OF AMINO ACIDS AS INHIBITORS OF RENIN, METHODS FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM AND THEIR USE HOECHST AKTIENGESELLSCHAFT (DE) 1992-05-14 WO claimed
EP-0483403-A1 Derivatives of amino acids as inhibitors of renin, methods for their preparation, medicaments containing them and their use HOECHST AKTIENGESELLSCHAFT (DE) 1992-05-06 EP claimed
WO-1992004370-A1 MODIFIED DI- AND TRIPEPTIDYL IMMUNOSUPPRESSIVE COMPOUNDS VERTEX PHARMACEUTICALS INCORPORATED (US) 1992-03-19 WO claimed
EP-0422937-A1 Fibrinogen receptor antagonists MERCK & CO. INC. (US) 1991-04-17 EP claimed
EP-0394853-A1 Dipeptide-derivatives with enzym-inhibiting activity HOECHST AKTIENGESELLSCHAFT (DE) 1990-10-31 EP claimed
CN-1043132-A Dipeptidase derivant with enzyme inhibition HOECHST AG (DE) 1990-06-20 CN claimed
US-4855286-A HYPOTENSIVE AGENTS HOECHST AKTIENGESELLSCHAFT (DE) 1989-08-08 US claimed
EP-0293159-A2 Parathyroid hormone antagonists with simplified synthetic methodology MERCK & CO. INC. (US) 1988-11-30 EP claimed