SCHEMBL14637816

SCHEMBL14637816

Cc1ncccc1Oc1ncnc(O[C@H]2CCN(C(=O)O)C[C@@H]2F)c1C

nearest known ligand 0.58

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ GPR119 Q8TDV5 20/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14639244 1.00 GPR119 (0.58) GPR119
SCHEMBL14637820 1.00 GPR119 (0.58) GPR119
SCHEMBL15388540 0.84 GPR119 (0.76) GPR119
SCHEMBL1768128 0.79 PIK3CD (0.39) GPR119
SCHEMBL298803 0.79 PIK3CD (0.39) GPR119
SCHEMBL288648 0.79 PIK3CD (0.39) GPR119
SCHEMBL14668825 0.79 GPR119 (0.66) GPR119
SCHEMBL757014 0.78 GPR119 (0.36) GPR119
SCHEMBL3512362 0.78 GPR119 (0.36) GPR119
SCHEMBL290047 0.78 GPR119 (0.36) GPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2731944-A1 GPR 119 MODULATORS Pfizer Inc (US) 2014-05-21 — — EP claimed
WO-2013011402-A1 GPR 119 MODULATORS PFIZER INC. (US) 2013-01-24 — — WO claimed
EP-2740458-B1 Packaging comprising forms of sodium salt of 4-tert-butyl-N-[4-chloro-2-(1-oxy-pyridine-4-carbonyl)-phenyl]-benzenesulfonamide IP GES FÜR MAN MBH (DE) 2016-08-03 — — EP disclosed
EP-2740458-A1 Packaging comprising forms of sodium salt of 4-tert-butyl-N-[4-chloro-2-(1-oxy-pyridine-4-carbonyl)-phenyl]-benzenesulfonamide IP Gesellschaft für Management mbH (DE) 2014-06-11 — — EP disclosed
EP-2731944-A1 GPR 119 MODULATORS Pfizer Inc (US) 2014-05-21 — — EP disclosed
WO-2013011402-A1 GPR 119 MODULATORS PFIZER INC. (US) 2013-01-24 — — WO disclosed
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