Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CDC25A | P30304 | 1/20 | 0.32 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12745666 | 1.00 | PRKCA (0.35) | PRKCAALOX12AKT1POLBCDC25A | |
| SCHEMBL12745665 | 0.86 | PRKCA (0.35) | PRKCAALOX12AKT1CDC25ASORT1 | |
| SCHEMBL12826430 | 0.83 | PRKCA (0.33) | PRKCAALOX12AKT1SORT1 | |
| SCHEMBL1463688 | 0.79 | SIRT2 (0.32) | POLB | |
| SCHEMBL12746067 | 0.77 | PRKCA (0.37) | PRKCAAKT1 | |
| SCHEMBL12745986 | 0.75 | DDB1 (0.41) | — | |
| SCHEMBL1463776 | 0.68 | — | — | |
| SCHEMBL12746030 | 0.65 | — | — | |
| SCHEMBL20150669 | 0.65 | — | — | |
| SCHEMBL18584058 | 0.65 | BLM (0.38) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9006231-B2 | Cephalotaxus esters, methods of synthesis, and uses thereof | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2015-04-14 | — | — | US | disclosed |
| US-20140343039-A1 | PROCESS FOR PREPARING CEPHALOTAXINE ESTERS | ROBIN JEAN-PIERRE (CH) | 2014-11-20 | — | — | US | disclosed |
| US-20140343039-A1 | PROCESS FOR PREPARING CEPHALOTAXINE ESTERS | ROBIN JEAN-PIERRE (CH) | 2014-11-20 | — | — | US | disclosed |
| US-20140171416-A1 | CEPHALOTAXUS ESTERS, METHODS OF SYNTHESIS, AND USES THEREOF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | 2014-06-19 | — | — | US | disclosed |
| US-8466142-B2 | Cephalotaxus esters, methods of synthesis, and uses thereof | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2013-06-18 | — | — | US | disclosed |
| US-8466142-B2 | Cephalotaxus esters, methods of synthesis, and uses thereof | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2013-06-18 | — | — | US | disclosed |
| US-20120022250-A1 | PROCESS FOR PREPARING CEPHALOTAXINE ESTERS | ROBIN JEAN-PIERRE (CH) | 2012-01-26 | — | — | US | disclosed |
| US-20120022250-A1 | PROCESS FOR PREPARING CEPHALOTAXINE ESTERS | ROBIN JEAN-PIERRE (CH) | 2012-01-26 | — | — | US | disclosed |
| US-20110071097-A1 | CEPHALOTAXUS ESTERS, METHODS OF SYNTHESIS, AND USES THEREOF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2011-03-24 | — | — | US | disclosed |
| US-20110071097-A1 | CEPHALOTAXUS ESTERS, METHODS OF SYNTHESIS, AND USES THEREOF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2011-03-24 | — | — | US | disclosed |
| EP-2260041-A2 | CEPHALOTAXUS ESTERS, METHODS OF SYNTHESIS, AND USES THEREOF | Sloan Kettering Institute For Cancer Research (US) | 2010-12-15 | — | — | EP | disclosed |
| WO-2009148654-A2 | CEPHALOTAXUS ESTERS, METHODS OF SYNTHESIS, AND USES THEREOF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2009-12-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110071097-A1 | CEPHALOTAXUS ESTERS, METHODS OF SYNTHESIS, AND USES THEREOF | COASY, CXCR4, CETP | PRKCA 2723/4885ALOX12 13/4885AKT1 1629/4885 |
| US-20120022250-A1 | PROCESS FOR PREPARING CEPHALOTAXINE ESTERS | CHRM1, OPRM1, CHRM2 | PRKCA 4497/4885ALOX12 575/4885AKT1 2040/4885 |
| US-20140343039-A1 | PROCESS FOR PREPARING CEPHALOTAXINE ESTERS | CFH, C5, CHRM1 | PRKCA 3547/4885ALOX12 299/4885AKT1 3281/4885 |
| US-20140171416-A1 | CEPHALOTAXUS ESTERS, METHODS OF SYNTHESIS, AND USES THEREOF | COASY, CXCR4, CETP | PRKCA 2723/4885ALOX12 13/4885AKT1 1629/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.