Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | G6PD | P11413 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 2/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14640464 | 0.80 | KMT2A (0.43) | ALDH1A1HPGDMAPTKMT2ARAB9A | |
| SCHEMBL5593627 | 0.77 | KMT2A (0.43) | ALDH1A1HPGDPKMMAPTKMT2A | |
| SCHEMBL5594434 | 0.76 | ALDH1A1 (0.50) | ALDH1A1HPGDPKMG6PDALOX15 | |
| SCHEMBL2808252 | 0.72 | ALDH1A1 (0.70) | ALDH1A1HPGDPKMG6PDALOX15 | |
| SCHEMBL3001943 | 0.72 | KMT2A (0.58) | ALDH1A1HPGDPKMMAPTKMT2A | |
| SCHEMBL19900671 | 0.71 | KMT2A (0.78) | ALDH1A1HPGDPKMMAPTKMT2A | |
| SCHEMBL5593583 | 0.71 | ALDH1A1 (0.68) | ALDH1A1HPGDPKMG6PDALOX15 | |
| SCHEMBL9322109 | 0.71 | ALDH1A1 (0.68) | ALDH1A1HPGDPKMG6PDALOX15 | |
| SCHEMBL9132689 | 0.71 | ALDH1A1 (0.68) | ALDH1A1HPGDPKMG6PDALOX15 | |
| SCHEMBL1879713 | 0.70 | ALDH1A1 (1.00) | ALDH1A1HPGDPKMG6PDALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007001932-A2 | SUBSTITUTED ISOTHIAZOLONES AS INHIBITORS OF CYTOSOLIC PHOSPHOLIPASE A2 | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-01-04 | — | — | WO | disclosed |