Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | KAT2B | Q92831 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14640600 | 0.87 | RAB9A (0.39) | KMT2ARAB9AKAT2BMEN1NPC1 | |
| SCHEMBL5593627 | 0.81 | KMT2A (0.43) | KMT2ARAB9AKAT2BMEN1NPC1 | |
| SCHEMBL14640431 | 0.80 | ALDH1A1 (0.53) | KMT2ARAB9AMEN1NPC1SMN1; SMN2 | |
| SCHEMBL5593605 | 0.77 | RAB9A (0.46) | KMT2ARAB9AKAT2BMEN1NPC1 | |
| SCHEMBL678175 | 0.74 | KAT2B (0.58) | KMT2AKAT2BMEN1MAPT | |
| SCHEMBL80967 | 0.71 | KAT2B (0.58) | KAT2BMAPTALDH1A1HPGDMGLL | |
| SCHEMBL95791 | 0.71 | KMT2A (0.58) | KMT2ARAB9AMEN1NPC1SMN1; SMN2 | |
| SCHEMBL3001943 | 0.71 | KMT2A (0.58) | KMT2ARAB9AMEN1NPC1SMN1; SMN2 | |
| SCHEMBL19900671 | 0.70 | KMT2A (0.78) | KMT2ARAB9AMEN1NPC1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9517520 | 0.70 | KAT2B (0.56) | KAT2BMAPTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007001932-A2 | SUBSTITUTED ISOTHIAZOLONES AS INHIBITORS OF CYTOSOLIC PHOSPHOLIPASE A2 | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-01-04 | — | — | WO | disclosed |