Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 3/20 | 0.47 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CTRC | Q99895 | 1/20 | 0.41 |
| ▸ | IDH1 | O75874 | 1/20 | 0.41 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14640460 | 0.75 | MAPT (0.56) | DAOMAPTHTTNPC1JAK2 | |
| SCHEMBL5593629 | 0.74 | KAT2B (0.49) | KAT2BDAOMAPTHTTALDH1A1 | |
| SCHEMBL17457962 | 0.68 | HTT (0.54) | DAOMAPTHTTNPC1JAK2 | |
| SCHEMBL718459 | 0.67 | PTGS1 (0.58) | DAOMAPTHTTALDH1A1CA12 | |
| SCHEMBL5593783 | 0.67 | NPBWR1 (0.41) | HTTALDH1A1CA12NPBWR1PIK3CA | |
| SCHEMBL1337353 | 0.66 | CA12 (0.57) | DAOMAPTHTTALDH1A1CA12 | |
| SCHEMBL28554314 | 0.66 | DAO (0.49) | DAOMAPTHTTCA12POLB | |
| SCHEMBL5798428 | 0.66 | DAO (0.56) | DAOMAPTHTTALDH1A1CA12 | |
| SCHEMBL31267076 | 0.66 | DAO (0.49) | DAOMAPTHTTALDH1A1CA12 | |
| SCHEMBL11865299 | 0.66 | HDAC1 (0.59) | DAOMAPTHTTALDH1A1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007001932-A2 | SUBSTITUTED ISOTHIAZOLONES AS INHIBITORS OF CYTOSOLIC PHOSPHOLIPASE A2 | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-01-04 | — | — | WO | disclosed |